Cranberry Enhances Human Immune Function and Reduces Illness
Клучни зборови
Апстракт
Опис
The study will be conducted as a randomized, double blind, placebo-controlled parallel trial. Subjects will be randomly assigned to either the Treatment (cranberry beverage) group or the Placebo group and each will be instructed to consume the test beverages twice a day for 70 days. The beverage is not commercially prepared juice, but is a beverage prepared with an extract of cranberry that contains polyphenols and proanthocyanidins. Blood is taken at baseline, and day 70. Subjects are given a diary to keep a record of their cold and flu symptoms. Serum is used to determine the antioxidant activity by the ORAC method. Peripheral blood mononuclear cells are isolated from the blood draw and used fresh, cultured for 24 hours or cultured for 10 days. Freshly isolated cells will be used to determine αβ-T, γδ-T, B and NK cell numbers and then cultured in autologous serum for 10 days to determine how well they proliferate. The supernatant of 24 hour cultures will be used for cytokine determination. If cells have been primed by the beverage made with cranberry compounds, the investigators expect the cells to proliferate to a greater extent and have modified cytokine production compared to placebo. If the beverage made with cranberry compounds enhances the proliferation of one or more of these cell types (αβ-T, γδ T, B or NK cell), then it is possible that there will be fewer cold and flu symptoms in the group consuming the cranberry beverage. Incidence of illness is not expected to change, only the severity of the illness.
Датуми
| Последен пат проверено: | 01/31/2010 |
| Прво доставено: | 07/17/2011 |
| Поднесено е проценето запишување: | 07/18/2011 |
| Прво објавено: | 07/19/2011 |
| Последното ажурирање е доставено: | 09/15/2011 |
| Последно ажурирање објавено: | 09/19/2011 |
| Крај на датумот на започнување на студијата: | 02/28/2009 |
| Проценет датум на примарно завршување: | 04/30/2009 |
| Проценет датум на завршување на студијата: | 04/30/2009 |
Состојба или болест
Интервенција / третман
Dietary Supplement: Sweetened Beverage
Dietary Supplement: Cranberry Beverage
Фаза
Групи за раце
| Рака | Интервенција / третман |
|---|---|
| Placebo Comparator: Sweetened Beverage looks like and is given in the same way as the experimental treatment but contains no active ingredient | Dietary Supplement: Sweetened Beverage one 15 ounce bottle of beverage consumed daily |
| Experimental: Cranberry Beverage 15 ounce bottle of cranberry beverage consumed daily for 70 days | Dietary Supplement: Cranberry Beverage one 15 ounce bottle consumed daily for 70 days |
Критериуми за подобност
| Возраст подобни за студии | 18 Years До 18 Years |
| Полови квалификувани за студии | All |
| Прифаќа здрави волонтери | Да |
| Критериуми | Inclusion Criteria: - Health male or non-pregnant female - Between the ages of 21 and 50 - BMI between 18 and 35 Exclusion Criteria: - High blood pressure define as 140/90 - Ongoing or chronic illness or infection - On hypertensive medication, immunosuppressive drugs, antibiotics, or chronic use of NSAIDS - Taking plant-based dietary supplements, antioxidant supplements, or probiotics - Vegetarian or strict vegan - Consume more than 1 cup of tea (iced or hot) per day - Consumes more than 2 glasses of alcoholic beverages per day - Consume more than 7 fruits and vegetables per day |
Исход
Мерки на примарниот исход
1. Physiological modifications to immune cell function [70 days]
Секундарни мерки на исходот
1. Cold and flu symptoms [70 days]
2. Anti-inflammatory outcome [70 days]
