Healthy Effects of an Innovative Probiotic Pasta
Клучни зборови
Апстракт
Опис
Epidemiological evidences indicate that consumption of whole grains products is associated to a decreased risk for common chronic diseases, as cardiovascular diseases, diabetes, obesity, hypertension and metabolic syndrome. In the present study a whole grain pasta was supplemented with prebiotics and probiotics 'ad hoc' formulated. In detail, pasta was industrially developed after the identification of particular cultivars of wheat and barley, rich in carotenoids, β-glucans (2.6 g/100g pasta), not soluble fibers and antioxidants. Further, pasta was supplemented with spores of Bacillus coagulans, a putative probiotic microorganism, belonging to Lactobacillus family. It is well demonstrated the ability of this microorganism to survive to technological processes and to upper gastro-intesinal tract, in order to exert beneficial effects in the lower gut, as anti-microbial activity, increasing immunological defences as well as improvements in intestinal regularity. Conversely, the control pasta was made from the same cultivar of grain and by the same technological process, but without any supplementation.
In this parallel randomized controlled one arm trial, 40 healthy volunteers were randomly allocated for the consumption of the two kind of pasta once a day, for 12 weeks. At the beginning of the study and every 4 weeks, subjects were asked to provide blood, urine and feces for the evaluation of:
- blood inflammation markers;
- blood lipid and carbohydrate profile;
- blood and urine markers of cardiovascular risk;
- feces profile of microbiota and detection of markers for the healthiness of the gut.
In addition, volunteers filled in different questionnaires regarding their dietary habits, the physical activity and the gut healthiness.
Датуми
| Последен пат проверено: | 09/30/2018 |
| Прво доставено: | 07/25/2014 |
| Поднесено е проценето запишување: | 09/06/2014 |
| Прво објавено: | 09/09/2014 |
| Последното ажурирање е доставено: | 10/29/2018 |
| Последно ажурирање објавено: | 10/31/2018 |
| Крај на датумот на започнување на студијата: | 02/28/2014 |
| Проценет датум на примарно завршување: | 08/31/2014 |
| Проценет датум на завршување на студијата: | 02/28/2015 |
Состојба или болест
Интервенција / третман
Dietary Supplement: whole grain pasta
Фаза
Групи за раце
| Рака | Интервенција / третман |
|---|---|
| Placebo Comparator: Control pasta Volunteers were fed with control pasta, without B-glucans and spores of B. coagulans once a day for 12 weeks. | |
| Experimental: Probiotic Whole Grain Pasta Volunteers were fed with probiotic fortified pasta, including B-glucans and spores of B. coagulans once a day for 12 weeks. |
Критериуми за подобност
| Возраст подобни за студии | 30 Years До 30 Years |
| Полови квалификувани за студии | All |
| Прифаќа здрави волонтери | Да |
| Критериуми | Inclusion Criteria: - Overweight / Obesity - Lower consumers of fruit and vegetables Exclusion Criteria: - Antibiotic treatment within 3 months prior the pasta feeding - Chronic diseases - Surgeries - Consumer of whole grain products - Dieting - Pregnant or lactating |
Исход
Мерки на примарниот исход
1. Variation of plasma lipids [12 weeks]
2. Variation of fecal microbiota composition [12 weeks]
3. Variation of antioxidant activity on fecal waters [12 weeks]
Секундарни мерки на исходот
1. Variation of body weight [12 weeks]
2. Variation of serum inflammatory marker concentration [12 weeks]
3. Variation of blood pressure [12 weeks]
4. Variation of body circumferences [12 weeks]
5. Variation of urine antioxidant marker [12 weeks]
