Dietary Fatty Acids, PPAR Activated Genes, and CHD
Клучни зборови
Апстракт
Опис
BACKGROUND:
Coronary heart disease (CHD) is the major cause of death in most industrialized and developing countries. Links between genetic and dietary factors that modify the risk of CHD should give fundamental insight into its causes and improve population-based CHD prevention strategies.
DESIGN NARRATIVE:
The study will identify genes that modulate the association between dietary fatty acids (FAs) and myocardial infarction (MI). The study uses DNA samples obtained during a population-based, case-control study in Costa Rica of 2,150 subjects who experienced myocardial infarctions and 2,150 matched controls. Biochemical measurements, dietary data, and general information are available for this population. One unique aspect of the study is that adipose tissue biomarkers of polyunsaturated FAs will be used to evaluate dietary exposure variables. Adipose tissue biomarkers (i.e., alpha-linolenic and linoleic acid) are very good indicators of intake in this population. Furthermore, this study showed that increased levels of these biomarkers in adipose tissue are strongly associated with decreased risk of MI, whereas an increase in 18:2 trans FAs increase the risk of MI. Gene-diet association studies and a "candidate pathway" approach will be used to elucidate genetic mechanisms that link risk of MI with exposure to polyunsaturated FAs [including cis and trans isomers of linoleic acid (n-6), and alpha-linolenic acid (n-3)]. The focus will be on peroxisome proliferator-activated receptor (PPAR) genes, and PPAR-regulated genes, that are involved in vascular inflammation. Among controls, the investigators will examine whether genetic and dietary factors independently affect biochemical markers (phenotypes) of the proposed genes. They will also test whether these phenotypes are more clearly identified when genetic and dietary factors are examined together. Because polyunsaturated FAs are important as activators of PPARs and their capacity to regulate gene expression at the level of transcription, this metabolic system is a suitable candidate for the study.
Датуми
Последен пат проверено: | 03/31/2017 |
Прво доставено: | 10/08/2003 |
Поднесено е проценето запишување: | 10/09/2003 |
Прво објавено: | 10/12/2003 |
Последното ажурирање е доставено: | 04/17/2017 |
Последно ажурирање објавено: | 04/19/2017 |
Крај на датумот на започнување на студијата: | 08/31/2003 |
Проценет датум на примарно завршување: | 07/31/2006 |
Проценет датум на завршување на студијата: | 07/31/2006 |
Состојба или болест
Фаза
Критериуми за подобност
Возраст подобни за студии | 18 Years До 18 Years |
Полови квалификувани за студии | All |
Метод на земање примероци | Probability Sample |
Прифаќа здрави волонтери | Да |
Критериуми | First acute MI Living in catchment area Randomly selected controls Matched for age sex and area of residence |