Effect of Dill in Thyroiditis and Nodular Goiter Patients

Само регистрираните корисници можат да преведуваат статии

Пријавете се / пријавете се

Врската е зачувана во таблата со исечоци

СтатусЗавршено

Спонзори

Bezmialem Vakif University

КЛИНИЧКО ИСПИТУВАЊЕ: NCT04482907

BioSeek: nct04482907

Клучни зборови

Апстракт

The aim of the study was to investigate the functional and morphological effects of Anethum graveolens L. in patients with thyroiditis and nodular goiter by evaluating hormone levels, anti-Inflammatory markers and comparing thyroid nodule sizes measured by ultrasonography for 90 days.

The effect of Anethum graveolens L. was evaluated in euthyroid goiter patients diagnosed with benign thyroid nodule via fine needle aspiration biopsy. Aerial parts of Anethum graveolens L. were dried and grinded to yield a fine powder. Size 1 hydroxypropyl methylcellulose capsules were filled with 300 mg powder. Placebo was prepared in the same manner using maltodextrin. Patients were suggested to take 3 pills a day. Blood samples were collected at the initial and the final day for thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (Anti-Tg) and C-reactive protein (CRP) analysis. Nodule sizes were also measured at the beginning and at the end of the trial with ultrasonography to identify the changes and effectiveness of dill dosage forms.

After 90 days in the study, the status of TSH, fT3, fT4, anti-TPO and CRP levels were examined in the group with and without Anethum graveolens L..

Again, after the study, the size of thyroid nodules was evaluated in the group who received and did not receive Anethum graveolens L. by ultrasonography.

Датуми

Последен пат проверено:	06/30/2020
Прво доставено:	07/15/2020
Поднесено е проценето запишување:	07/19/2020
Прво објавено:	07/22/2020
Последното ажурирање е доставено:	07/19/2020
Последно ажурирање објавено:	07/22/2020
Крај на датумот на започнување на студијата:	01/31/2019
Проценет датум на примарно завршување:	12/15/2019
Проценет датум на завршување на студијата:	04/04/2020

Состојба или болест

Thyroid Nodule

Интервенција / третман

Dietary Supplement: Giving dill by mouth capsule to the study group and placebo capsule by mouth to the control group.

Фаза

Групи за раце

Рака	Интервенција / третман
Active Comparator: Group receiving dill They took 3 meals a day, 3x300 mg dry dill powder by mouth. They bought dry dill powder for 90 days.
Placebo Comparator: Group receiving placebo They took 3 meals a day and 3 cellulose placebo capsules by mouth. They took placebo capsules for 90 days.

Критериуми за подобност

Возраст подобни за студии	18 Years До 18 Years
Полови квалификувани за студии	All
Прифаќа здрави волонтери	Да
Критериуми	Inclusion Criteria: - To have multi-nodular goiter, - To be a benign result in fine needle aspiration biopsy, - Euthyroid must be sick, - Must be sick over the age of 18, - To accept the research. Exclusion Criteria: - Thyroid function tests non-euthyroid individuals, - To have a malignant result in thyroid biopsy, - Not giving approval, - To be renal failure, - Benign pregnant, - Taking blood thinning drugs

Исход

Мерки на примарниот исход

1. Comparison of thyroid stimulating hormone (TSH) between groups [90 days]

At the beginning and at the end of the study, the levels of serum TSH were measured and statistically compared in groups given Anethum graveolens L. and placebo.

2. Comparison of free triiodothyronine (fT3) between groups [90 days]

At the beginning and at the end of the study, the levels of serum fT3 were measured and statistically compared in groups given Anethum graveolens L. and placebo.

3. Comparison of free thyroxine (fT4) between groups [90 days]

At the beginning and at the end of the study, the levels of serum fT4 were measured and statistically compared in groups given Anethum graveolens L. and placebo.

4. Comparison of anti-thyroid peroxidase (anti-TPO) between groups [90 days]

At the beginning and at the end of the study, the levels of anti-TPO were measured and statistically compared in groups given Anethum graveolens L. and placebo.

5. Comparison of anti-thyroglobulin (Anti-Tg) between groups [90 days]

At the beginning and at the end of the study, the levels of serum Anti-Tg were measured and statistically compared in groups given Anethum graveolens L. and placebo.

6. Comparison of C-reactive protein (CRP) between groups [90 days]

At the beginning and at the end of the study, the levels of serum CRP were measured and statistically compared in groups given Anethum graveolens L. and placebo.

7. Comparison of ultrasound and thyroid nodule sizes between groups [90 days]

At the beginning and end of the study, thyroid nodule sizes (mm) were measured and statistically compared in groups given Anethum graveolens L. and placebo.

Effect of Dill in Thyroiditis and Nodular Goiter Patients

Клучни зборови

peroxidase

thyroid nodule

inflammation

goiter

thyroiditis

anethum

ко́пар

антиинфламаторно

антитироиден