Mitochondrial Energy Metabolism in Obese Women
Клучни зборови
Апстракт
Опис
Specific objectives:
Body composition by deuterium oxide; Metabolic rate of resting and oxidation of substrates by indirect calorimetry; Proinflammatory cytokines Anti-inflammatory cytokines Oxidative Stress: Malondialdehyde, Superoxide Dismutase, Glutathione-Peroxidase; Fatty acids: ceramide and palmitate; Mitochondrial respiration and citrate synthase enzyme; Quantify and qualify: mitochondrial number, endoplasmic reticulum structure, adipose cell size; Gene expression, quantify by microscopy and analyze the protein by western blot.
The study began with 20 women, however, there was withdrawal of 6, ending with 14 women.
Датуми
| Последен пат проверено: | 03/31/2019 |
| Прво доставено: | 04/09/2017 |
| Поднесено е проценето запишување: | 04/12/2017 |
| Прво објавено: | 04/17/2017 |
| Последното ажурирање е доставено: | 04/26/2019 |
| Последно ажурирање објавено: | 04/29/2019 |
| Крај на датумот на започнување на студијата: | 03/31/2016 |
| Проценет датум на примарно завршување: | 06/30/2016 |
| Проценет датум на завршување на студијата: | 09/14/2016 |
Состојба или болест
Интервенција / третман
Other: Physical Training
Фаза
Групи за раце
| Рака | Интервенција / третман |
|---|---|
| Other: Physical Training There was concurrent physical training intervention: strength and aerobic exercises in the same session.
Duration: 2 weeks of adaptation and learning to exercise, 8 weeks of physical training.
Frequency: 3 times per week Duration: 55 minutes each session. Intensity: 75 to 90% of maximum heart rate. | Other: Physical Training Intervention with concurrent physical training: strength and aerobic exercises in the same session.
Duration: 2 weeks of adaptation to physical exercise, 8 weeks of training. Frequency: 3 times a week. Time: 55 minutes each session. Intensity: 75 to 90% of maximum heart rate. |
Критериуми за подобност
| Возраст подобни за студии | 20 Years До 20 Years |
| Полови квалификувани за студии | Female |
| Прифаќа здрави волонтери | Да |
| Критериуми | Inclusion Criteria: - This study included women with obesity (BMI of 30 to 40 kg / m²), sedentary, with no associated comorbidity, convenience sample Exclusion Criteria: - Women who have undergone bariatric surgery, menopause, cancer or any metabolic disease, smokers, alcoholics, who are in use of drugs that act directly on the metabolism and that have medical impediment to the practice of physical exercise. |
Исход
Мерки на примарниот исход
1. Changes Body weight [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
2. Changes Body composition [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
3. Changes White adipose tissue biopsy [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
4. Changes Indirect calorimetry [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
5. Changes in fatty acids [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
6. Changes oxidative stress [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
7. Changes inflammatory cytokines [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
8. Changes in total cholesterol [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
9. Changes Physical Performance [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
10. Changes in Determination of Lactate [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
11. Changes Food intake [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
12. Changes Nitrogen Balance [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
13. Changes Telomere length [Two times: (1) First day and (2) 10 weeks after adaptation and intervention]
