Modified Atkins Diet for Overweight and Obesity
Клучни зборови
Апстракт
Опис
The mechanisms of obesity are complex, involved in genes, environment, life style, and systemic and adipose tissue inflammation. Dysbiosis of gut microbiome is considered to make a difference in obesity. On the other hand, both long-term and short-term dietary interventions can induce changes in the body composition and structure and function of gut microbiome. However, it is not really clear how gut microbiome changes along with weight loss in overweight or obese.
In the present study, investigators aim to characterize the gut microbiome among overweight or obese participants on a modified Atkins diets. The stool and blood samples were collected by an interval of every 5% and 10% of weight loss, respectively. Data collecting mainly covers: 1) body composition analysis ; 2) obesity related biochemical metabolism; 3) measurement of gut microbiome using metagenome and 16S rRNA sequencing techniques; 4) metabolomics of serum and gut microbiome; 5) measurement of physical activity and diets using questionnaires.
Датуми
| Последен пат проверено: | 12/31/2019 |
| Прво доставено: | 12/03/2019 |
| Поднесено е проценето запишување: | 12/17/2019 |
| Прво објавено: | 12/22/2019 |
| Последното ажурирање е доставено: | 01/08/2020 |
| Последно ажурирање објавено: | 01/12/2020 |
| Крај на датумот на започнување на студијата: | 01/31/2020 |
| Проценет датум на примарно завршување: | 11/30/2022 |
| Проценет датум на завршување на студијата: | 11/30/2025 |
Состојба или болест
Фаза
Групи за раце
| Рака | Интервенција / третман |
|---|---|
| weight loss group Dynamic changes in body composition, biochemical metabolomics and gut microbiome will be reported among overweight and obese patients. |
Критериуми за подобност
| Возраст подобни за студии | 18 Years До 18 Years |
| Полови квалификувани за студии | All |
| Метод на земање примероци | Non-Probability Sample |
| Прифаќа здрави волонтери | Да |
| Критериуми | Inclusion Criteria: 1. 18-55 years old; 2. BMI > 23.9kg/m2; 3. being willing and able to receive guidelines to a modified Atkins diet; 4. signed informed consent. Exclusion Criteria: 1. patients with serious physical and mental diseases (including cardiovascular and cerebrovascular diseases, liver and kidney diseases, respiratory diseases gastrointestinal diseases, mental diseases, etc.); 2. patients with malignant tumor; 3. pregnant and lactating women; 4. those with recent relocation plans. |
Исход
Мерки на примарниот исход
1. Dynamic changes of gut microbiome [36 months]
2. Dynamic changes in faecal metabolomics [36 months]
Секундарни мерки на исходот
1. Dynamic changes of body mass index [36 months]
2. Dynamic changes of body fat [36 months]
3. Dynamic changes of muscle mass [36 months]
4. Dynamic changes of blood lipids [36 months]
5. Dynamic changes of fasting blood glucose [36 months]
6. Dynamic changes of homocysteine [36 months]
7. Dynamic changes of blood pressure [36 months]
