Bioorganic and Medicinal Chemistry 2005-Jul
A prenylbisabolane with NF-kappaB inhibiting properties from Cascarilla (Croton eluteria).
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Клучни зборови
Апстракт
Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-kappaB by tumor necrosis factor-alpha in T cells.
