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Combination therapy with artemisinin derivatives is the treatment of choice for malaria by P. falciparum since 2006, but there is growing evidence of the emergence of P. falciparum resistance to artesunate in Southeast Asia. The delayed clearance of parasitemia for more than 24 hours has been taken
There is evidence from several studies that in areas where the transmission of malaria is seasonal, the use of IPT can reduce substantially the incidence of clinical malaria in children under the age of five years, by as much as 90% (Greenwood et al, Trends in Parasitology 24(11):485-6, 2008). The
Plasmodium falciparum malaria kills over one million people and results in up to 500 million cases annually affecting mainly young children and pregnant women. The economic consequences of malaria are enormous in endemic regions with an estimated USD 12 billion per year lost GDP and a loss of 45