bone neoplasms/калиум

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Role of ATP-sensitive potassium channels in modulating nociception in rat model of bone cancer pain.

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Bone cancer pain is a major clinical problem and remains difficult to treat. ATP-sensitive potassium (KATP) channels may be involved in regulating nociceptive transmission at the spinal cord level. We determined the role of spinal KATP channels in the control of mechanical hypersensitivity in a rat

Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.

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Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat. Better understanding of the pathogenic mechanisms underlying bone cancer pain will likely lead to the development of more effective treatments. In the present study, we investigated whether inhibition

[Effect of cinobufagin on transient outward potassium current in dorsal root ganglion cells of rats with cancer-induced bone pain].

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OBJECTIVE

To observe the effect of cinobufagin on transient outward potassium current (I_A) in rat dorsal root ganglion cells of cancer-induced bone pain (CIBP) and explore the possible analgesic mechanism of cinobufagin.

METHODS

Whole cell

G protein-gated inwardly rectifying potassium (KIR3) channels play a primary role in the antinociceptive effect of oxycodone, but not morphine, at supraspinal sites.

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OBJECTIVE Oxycodone and morphine are μ-opioid receptor agonists prescribed to control moderate-to-severe pain. Previous studies suggested that these opioids exhibit different analgesic profiles. We hypothesized that distinct mechanisms mediate the differential effects of these two opioids and

Emerging potassium channel targets for the treatment of pain.

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OBJECTIVE Poor management of chronic pain remains a significant cause of misery with huge socioeconomic costs. Accumulating research in potassium (K+) channel physiology has uncovered several promising leads for the development of novel analgesics. RESULTS We now recognize that certain K+ channel

Suppression of WNK1-SPAK/OSR1 Attenuates Bone Cancer Pain by Regulating NKCC1 and KCC2.

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Our preliminary experiment indicated the activation of with-nolysine kinases 1 (WNK1) in bone cancer pain (BCP) rats. This study aimed to investigate the underlying mechanisms via which WNK1 contributed to BCP. A rat model of BCP was induced by Walker-256 tumor cell implantation. WNK1 expression and

Effects of the potassium-sparing diuretic amiloride on chemotherapy response in canine osteosarcoma cells.

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Osteosarcoma (OSA) is a common bone tumor of mesenchymal origin in dogs. Chemotherapy delays metastasis, yet most dogs die of this disease within 1 year of diagnosis. The high metabolic demand of cancer cells promotes proton pump upregulation, leading to acidification of the tumor

Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain.

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Epigenetic modulation participates in the mechanism of multiple types of pathological pain, so targeting the involved regulators may be a promising strategy for pain treatment. Our previous research identified the analgesic effect of the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) on

[Biological effect of controlled fluid hyperthermia on rabbit healthy bones].

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Fluid hyperthermia has been used to treat various types of cancers, but its effects on bone have not been determined. The purpose of this prospective study was to show the structural and metabolic changes of bone exposed to fluid hyperthermia and the effects of the latter on bone healing. Thirty New

[Infrared spectroscopy of the dry urinary residue of healthy persons].

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Dry urine residue and mineralized dry urine of clinically healthy subjects, aged from 2 months to 94 years were investigated by the method of infrared spectroscopy in Nujol and in tablets of potassium bromide. The subjects examined were subdivided into 4 age groups -- I group, children aged from 2

The possible influence of the components of the soil and the lithosphere on the development and growth of neoplasms.

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The author reviews the background of the soil-cancer relationship. The study then goes into geocarcinogenic diseases in relation to soil composition, looking first at general factors: soil concentrations of selenium, caesium-rubidium-potassium, trace elements; natural radioactivity risks; cancer

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