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The author presents a case with spontaneous perforation of the cornea after extracapsular cataract extraction in a female patient with rheumatoid arthritis. Systemic disorganization of the connective tissue and elevated collagenase activity essentially contribute to the pathogenesis of corneal
Zinc ions were shown to reversibly inhibit the activity of Pseudomonas protease. Zinc sulfate was more effective topically in preventing corneal perforations by this enzyme than either cysteine or edetate disodium (Na2 EDTA). The reversibility of the enzyme inactivation by zinc sulfate and its
Pseudomonas aeruginosa and Serratia marcescens can cause refractory keratitis resulting in corneal perforation and blindness. These bacteria produce various kinds of proteases. In addition to pseudomonal elastase (LasB) and alkaline protease, LasA protease and protease IV have recently been found to