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7 резултати
Current management of secondary hyperparathyroidism: a multicenter observational study (COSMOS).
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OBJECTIVE
To survey bone mineral disturbances in the hemodialysis (HD) population in Europe and current clinical practice in Europe for the prevention, diagnosis and treatment of secondary hyperparathyroidism (SHPT) in HD patients.
OBJECTIVE
First, to estimate the prevalence of Kidney Disease
Prediction of blood-brain partitioning and human serum albumin binding based on COSMO-RS sigma-moments.
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Models for the prediction of blood-brain partitioning (logBB) and human serum albumin binding (logK(HSA)) of neutral molecules were developed using the set of 5 COSMO-RS sigma-moments as descriptors. These sigma-moments have already been introduced earlier as a general descriptor set for partition
Cosmos 1887 mission overview: effects of microgravity on rat body and adrenal weights and plasma constituents.
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The Cosmos 1887 biosatellite carried 10 male rats and 2 rhesus monkeys on its 12.5-day mission. Upon re-entry the Vostok vehicle overshot the designated landing site, which resulted in fasting of the animals for 42 h, exposure to cage temperatures of 12-15 degrees C, and 2 days delay in death of the
Examining the clinical course of genotype 1 chronic hepatitis C patients treated with the cosmos regimen: including patients with advanced liver disease and East Asian ancestry.
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OBJECTIVE
The COSMOS study was a phase 2a clinical trial that showed high cure rates of genotype 1 chronic hepatitis C (CHC) and a favorable side effect profile using a 12-week regimen of simeprevir + sofosbuvir (SIM + SOF). Given the small number of patients treated with the SIM + SOF regimen in
Comparison of the antialbuminuric effects of benidipine and hydrochlorothiazide in Renin-Angiotensin System (RAS) inhibitor-treated hypertensive patients with albuminuria: the COSMO-CKD (COmbination Strategy on Renal Function of Benidipine or Diuretics TreatMent with RAS inhibitOrs in a Chronic Kidney Disease Hypertensive Population) study.
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OBJECTIVE
This study evaluated the non-inferiority of renoprotection afforded by benidipine versus hydrochlorothiazide in hypertensive patients with chronic kidney disease (CKD).
METHODS
In this prospective, multicenter, open-labeled, randomized trial, the antialbuminuric effects of benidipine and
Screening tools for the bioconcentration potential of monovalent organic ions in fish.
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Currently the bioaccumulation potential of organic chemicals is assessed in a first tier approach via their octanol-water partition coefficient. This approach has been developed for neutral chemicals and cannot work for ionizable and ionic chemicals because the latter have different
Good's Buffer Ionic Liquids as Relevant Phase-Forming Components of Self-Buffered Aqueous Biphasic Systems.
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A series of new self-buffering ionic liquids (ILs) based on Good's buffers (GBs) anions and the tetrabutylphosphonium cation ([P4444]+) was here synthesized and characterized. The self-buffering behaviour of the GB-ILs was confirmed by measuring their protonation constants by potentiometry. Further,
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