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Livers from rats flown aboard COSMOS 2044 were analyzed for protein, carbohydrate (glycogen), and lipids as well as the activities of a number of key enzymes involved in metabolism of these compounds and xenobiotics. The major differences between the flight group and the synchronous control were
The indicators of adrenomedullary activity (catecholamine content (CA) and the activity of the catecholamine-synthesizing enzymes tyrosine hydrozylase (TH) and dopamine-beta-hydrozylase (DBH) were measured in the adrenal glands of rats living in a state of weightlessness for 18.5-19.5 days on board
After the 18.5-day flight on board the biosatellite Cosmos-936, the activity of 6 glucocorticoid-activated enzymes in the rat liver was investigated. It was found that at R+O activities of tyrosine aminotransferase and tryptophane pyrrolase, as well as fructose-1,6-diphosphatase,
The activity of the catecholaminergic system was measured in the hypothalamus of rats which had experienced an 18.5-19.5-day-long stay in the state of weightlessness during space flights on board Soviet biosatellites of the type Cosmos. In the first two experiments, Cosmos 782 and 936, the
In the adrenals of weightless and centrifuged rats flown for 18.5 days onboard the biosatellite Cosmos-936 indicators of the activity of the adrenomedullary system, i.e. the content of catecholamines and activity of the enzymes involved in their synthesis--tyrosine hydroxylase and
The aim of present experiment was to study the changes of corticosterone, insulin and glucose levels in plasma, of the activity of enzymes involved in aminoacid metabolism in liver and the binding of insulin to specific receptors of cell membrane from liver and also of adipose tissue of rats exposed
A study on the interaction between a phosphotyrosyl peptide with the SH2 domain of Lck kinase has been undertaken with the aid of semiempirical linear-scaling quantum mechanical methods. The structure of this complex has been solved at atomic resolution and, hence, it represents the ideal candidate
Three cosmic experiments were performed in which rats spent 18-20 days in space on board the biosatellites "COSMOS 782", "COSMOS 936" and "COSMOS 1129". The following indicators of the sympathetic-adrenomedullary system (SAS) activity were measured: tissue and plasma catecholamines (CA),
It is demonstrated that the fluid-phase thermodynamics theory conductor-like screening model for real solvents (COSMO-RS) as implemented in the COSMOtherm software can be used for accurate and efficient screening of coformers for active pharmaceutical ingredient (API) cocrystallization. The excess
After a 18.5-day space flight on Cosmos-1129 rat adrenals were investigated for the concentration of catecholamines and activity of enzymes involved in their synthesis, i.e. tyrosine hydroxylase, dopamine-beta-hydroxylase, and phenyl ethanol amine-N-methyl transferase. It was found that inflight the
In the hypothalamus of the weightless and centrifuged rats flown for 18.5 days on board the biosatellite Cosmos-936 the noradrenaline concentration and activity of the enzymes involved in the catecholamine synthesis and degradation were measured. It was found that under the space flight influence
The concentration of catecholamines, and activity of enzymes involved in their synthesis (tyrosine hydroxylase and dopamine-beta-hydroxylase) and degradation (monoamine oxidase) were measured in the hypothalamus of rats flown for 19.5 days aboard the biosatellite Cosmos-782, synchronous and vivarium
Time Dependent Density Functional Theory (TDDFT) along with the COnductor-like Screening MOdel (COSMO) has been applied to model the specific rotation at 589.3 nm and the optical rotatory dispersion (ORD) of the aromatic amino acids phenylalanine, tyrosine, histidine, and tryptophan. Solution
Concentrations of corticosteron and catecholamines, and activities of catecholamine synthesizing enzymes, tyrosine hydroxylase, dopamine-beta-hydroxylase and phenyl ethanol amine-N-methyl-transferase, were measured in the adrenals of rats flown for 19.5 days aboard the biosatellite Cosmos-782,
After the 18.5 day Cosmos-1129 flight the activity of 7 glucocorticoid-stimulated enzymes of the rat liver was measured. Immediately postflight the activity of tyrosine aminotransferase, tryptophan pyrolase and serine dehydrogenase increased. These enzymes rapidly (within several hours) react to