Compounds of formula (I) and pharmaceutically acceptable salts thereof, where G is a methylene or ethylene linkage; R.sup.1 is hydrogen, C.sub.1-6 alkylO--; R.sup.2 is hydrogen, halogen, CN, N.sub.3, trifluoromethyldiazirinyl, CF.sub.3, CF.sub.3 O--, CF.sub.3 S--, CF.sub.3 CO--, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl-, C.sub.1-6 alkylO--, C.sub.1-6 alkylCO--, C.sub.3-6 cycloalkylCO--, C.sub.3-6 cycloalkyl-C.sub.1-4 -alkylCO--, phenyl, phenoxy, benzyloxy, benzoyl and substituted benzoyl, phenyl-C.sub.1-4 alkyl-, C.sub.1-6 alkylSO.sub.2 --, (C.sub.1-4 alkyl).sub.2 NSO.sub.2 -- or (C.sub.1-4 alkyl)NHSO.sub.2 --; R.sup.3 is hydrogen, halogen, CN, N.sub.3, trifluoromethyldiazirinyl, C.sub.1-6 alkylO--, C.sub.1-6 alkylS--, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl-, C.sub.1-6 alkenyl, C.sub.1-6 alkynyl, CF.sub.3 CO--, C.sub.1-6 alkylCO--, C.sub.3-6 cycloalkylCO--, C.sub.3-6 cycloalkyl-C.sub.1-4 alkylCO--, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C.sub.1-4 alkyl-, or --NR.sup.5 R.sup.6 where R.sup.5 is hydrogen or C.sub.1-4 alkyl; and R.sup.6 is hydrogen, C.sub.1-4 alkyl, --CHO, --CO.sub.2 C.sub.1-4 alkyl or --COC.sub.1-4 alkyl; R.sup.4 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkenyl, or C.sub.1-6 alkynyl, are useful in the prevention and treatment of anxiety, mania, depression disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alcohol and benzodiazepines, disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson's disease, psychosis, migraine, etc. ##STR1##

epilepsy post-traumatic/никотин

Substituted benzamide derivatives and pharmaceutical compositions containing them

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