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fibromyalgia/повраќање
Врската е зачувана во таблата со исечоци
Страница 1 од 36 резултати
Sodium oxybate reduces pain, fatigue, and sleep disturbance and improves functionality in fibromyalgia: results from a 14-week, randomized, double-blind, placebo-controlled study.
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This 14-week, phase 3, double-blind, randomized, controlled trial evaluated sodium oxybate (SXB) 4.5 and 6g per night versus placebo in patients with fibromyalgia (FM). SXB is the sodium salt of γ-hydroxybutyrate (GHB). GHB is an endogenous compound, synthesized from γ-aminobutyric acid (GABA) and
Sodium oxybate therapy provides multidimensional improvement in fibromyalgia: results of an international phase 3 trial.
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BACKGROUND
Fibromyalgia is characterised by chronic musculoskeletal pain and multiple symptoms including fatigue, multidimensional function impairment, sleep disturbance and tenderness. Along with pain and fatigue, non-restorative sleep is a core symptom of fibromyalgia. Sodium oxybate (SXB) is
Long-term tolerability and maintenance of therapeutic response to sodium oxybate in an open-label extension study in patients with fibromyalgia.
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BACKGROUND
The long-term safety and therapeutic response of sodium oxybate (SXB) in fibromyalgia syndrome (FM) patients were assessed for a combined period of up to 1 year in a prospective, multicenter, open-label, extension study in patients completing 1 of 2 phase 3 randomized, double-blind,
A 1-year safety and efficacy study of duloxetine in patients with fibromyalgia.
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OBJECTIVE
Evaluate the efficacy and safety of duloxetine at doses up to 120 mg once daily in patients with fibromyalgia.
METHODS
This was a phase 3, 60-week study, which included an 8-week open-label period followed by a 52-week, randomized, double-blind period. Patients received duloxetine 30 mg
Preliminary experience using milnacipran in patients with juvenile fibromyalgia: lessons from a clinical trial program.
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BACKGROUND
There are no approved medications for juvenile fibromyalgia (JFM), a disorder that is often under-diagnosed. The effects of milnacipran, a drug approved for the management of fibromyalgia (FM) in adults, was assessed in a clinical trial program for JFM.
METHODS
Patients, ages 13-17 years
Prevalence of functional gastrointestinal disorders in patients with fibromyalgia and the role of psychologic distress.
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OBJECTIVE
Fibromyalgia is a rheumatologic disorder associated with somatic and psychologic conditions. Although fibromyalgia is associated with irritable bowel syndrome, its relationship with other functional gastrointestinal disorders (FGID) is unclear. We evaluated the prevalence of FGID in
Monoamine oxidase inhibitors (MAOIs) for fibromyalgia syndrome.
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BACKGROUND
Fibromyalgia (FM) syndrome is a chronic condition of unknown aetiology characterised by musculoskeletal pain that often co-exists with sleep disturbance, cognitive dysfunction and fatigue. Patients often report high disability levels and poor quality of life. Since there is no specific
Ultramicronized Palmitoylethanolamide (um-PEA) as Add-on Treatment in Fibromyalgia Syndrome (FMS): Retrospective Observational Study on 407 Patients.
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Increased frequency of gastrointestinal symptoms in patients with fibromyalgia and associated factors: a comparative study.
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OBJECTIVE
To determine the frequency and severity of gastrointestinal (GI) symptoms in patients with fibromyalgia (FM).
METHODS
We included 152 women with FM (mean age 45.4 +/- 12.2 yrs), 98 women with rheumatoid arthritis (RA; mean age 45.5 +/- 12.3 yrs), and 60 healthy female controls (mean age 44
The promise of substance P inhibitors in fibromyalgia.
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The discovery of SP and its potent biological activities have lead to the discovery of other tachykinins and to receptors for them, including the NK1 receptor. Blockade of the NK1 receptor has a number of potentially beneficial effects in medical care including the management of drug-induced emesis
Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions.
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The symptom intensity and mortality of human diseases, conditions, and syndromes exhibit diurnal or 24 h patterning, e.g., skin: atopic dermatitis, urticaria, psoriasis, and palmar hyperhidrosis; gastrointestinal: esophageal reflux, peptic ulcer (including perforation and hemorrhage), cyclic
Substance P and Substance P receptor antagonists in the pathogenesis and treatment of affective disorders.
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Substance P (SP) is a neuropeptide which is widely distributed in the periphery and the central nervous system (CNS), where it is co-localised with other neurotransmitters such as serotonin or dopamine and where it acts as a neuromodulator. SP has been proposed to play a role in the aetiopathology
Droperidol analgesia for opioid-tolerant patients.
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BACKGROUND
Patients with acute and chronic pain syndromes such as migraine headache, fibromyalgia, and sickle cell disease represent a significant portion of emergency department (ED) visits. Certain patients may have tolerance to opioid analgesics and often require large doses and prolonged time in
A commentary on the medicinal use of marijuana.
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5-HT3 receptors.
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5-HT(3)-receptor antagonists are highly selective competitive inhibitors of the 5-HT(3)-receptor with negligible affinity for other receptors. They are potent, rapidly absorbed and easily penetrate the blood-brain barrier; metabolized by the cytochrome P450-system with half-life varying from 3-10
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