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grayanotoxin/rhododendron

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Extracts from Rhododendron ferrugineum do not exhibit grayanotoxin I: an analytical survey on grayanotoxin I within the genus Rhododendron.

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For quantitative determination of grayanotoxin I (1) in plant material, a GC/MS method was developed after trimethylsilyl derivatisation of the analytes. Forskolin (5) was used as an internal standard for quantification. ICH-compliant method validation indicated sufficient specificity, precision,

Determination of Grayanotoxins from Rhododendron brachycarpum in Dietary Supplements and Homemade Wine by Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometry and Liquid Chromatography-Tandem Mass Spectrometry.

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A sensitive and specific high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (LC-QTOF-MS) method combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the determination of grayanotoxins I and III in dietary supplements and homemade

Grayanotoxin poisoning from Rhododendron simsii in an infant.

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We report a case of severe poisoning in a 57-day-old infant who presented with vomiting, convulsions, and shock after ingesting a bottle of milk containing a decoction of Rhododendron simsii. The grandmother collected this toxic plant from a cultivated area, believing it was good for the airways.

Site of action of grayanotoxins in mad honey in rats.

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Grayanotoxins are known to occur in honey produced from the nectar of Rhododendrons of the family Ericaceae. Grayanotoxins extracted from honey sample obtained from a patient who experienced severe bradycardia and hypotension after ingesting two tablespoonfuls corresponded to Rhododendron ponticum

A new 1,5-seco grayanotoxin from Rhododendron decorum.

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A new minor 1,5-seco-5-oxo-grayanotoxin named grayanotoxin XXI (1), together with three known grayanotoxins, grayanotoxins I, IV and VIII, has been isolated from the leaves of Rhododendron decorum (Ericaceae). The structure of the new compound (1) was determined on the basis of spectroscopic data.

Acute effects of grayanotoxin in rhododendron honey on kidney functions in rats.

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The aim of the study is to evaluate the acute biochemical and histological changes in rat kidneys after treatment with grayanotoxin (GTX) of rhododendron honey (RH). A total of 60 Sprague-Dawley female rats were divided into five groups of 12 rats each, one being a control group (group 1) and group

Grayanotoxin poisoning from flower of Rhododendron mucronulatum in humans.

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Grayanotoxin poisoning from flower of Rhododendron mucronulatum in humans.

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Poisonous delicacy: Market-oriented surveys of the consumption of Rhododendron flowers in Yunnan, China

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Ethnopharmacological relevance: Plants from the family Ericaceae, and in particular those in the genus Rhododendron are frequently reported to contain grayanotoxins. Plant products such as honey and herbal medicines made from these plants

Degradation of yew, ragwort and rhododendron toxins during composting.

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Recent concerns have been raised that plants such as ragwort (Senecio jacobaea), yew (Taxus baccata) and rhododendron (Rhododendron ponticum) that are toxic to livestock may be included in compost windrows but may not be fully detoxified by the composting process. This study investigates the

Leaf trichomes and foliar chemistry mediate defence against glasshouse thrips; Heliothrips haemorrhoidalis (Bouché) in Rhododendron simsii

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Herbivore defence mechanisms are a costly diversion of resources away from growth and reproduction. Thus time-limited and tissue specific expression in critical plant parts is more efficient as defined by optimal defence theory. Surprisingly little is known about Rhododendron herbivore defence but

Atrioventricular block induced by mad-honey intoxication: confirmation of diagnosis by pollen analysis.

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An unusual type of food poisoning, mad-honey intoxication, can be observed in the Black Sea region of Turkey and various other parts of the world. It can occur after ingestion of grayanotoxin-contaminated honey produced from the nectar of Rhododendron ponticum and other plant species, chiefly of the

Mad-honey sexual activity and acute inferior myocardial infarctions in a married couple.

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Mad-honey poisoning can occur after the eating of honey that contains grayanotoxin. Mad honey is intentionally produced from the nectar of Rhododendron ponticum, which grows in Japan, Nepal, Brazil, parts of North America and Europe, and the eastern Black Sea region of Turkey. Low doses of

Labrador tea--the aromatic beverage and spice: a review of origin, processing and safety.

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Labrador tea is a name for the dried leaves of Rhododendron groenlandicum, R. tomentosum or R. neoglandulosum (family Ericaceae, previously genus Ledum) as well as for the beverage native to North America, which is made from them. The above species are rich in the essential oil, which gives a

Grayanane Diterpenoids from the Leaves of Rhododendron auriculatum and Their Analgesic Activities.

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Twenty-four grayanane diterpenoids (1-24) including 12 new ones (1-12) were isolated from Rhododendron auriculatum. The structures of the new grayanane diterpenoids (1-12) were defined via extensive spectroscopic data analysis. The absolute
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