methoxsalen/inflammation

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Methoxsalen supplementation attenuates bone loss and inflammatory response in ovariectomized mice.

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Methoxsalen (MTS) is a natural bioactive compound found in a variety of plants that has many known biofunctions; however, its effects on osteoporosis and related mechanisms are not clear. This study examined whether MTS exhibited preventive effects against postmenopausal osteoporosis. Female C3H/HeN

PUVA therapy for polymorphous light eruptions: comparison of systemic methoxsalen and topical trioxsalen regimens and evaluation of local protective mechanisms.

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Twenty-six patients with long-standing, recurrent polymorphous light eruptions were treated with psoralen photochemotherapy. Thirteen patients received oral methoxsalen, while 13 were photosensitized by trioxsalen baths. After an average of 20 PUVA exposures, a good or excellent therapeutic result

Prolonged skin photosensitization induced by methoxsalen and subphototoxic UVA irradiation.

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Topical 8-methoxypsoralen (8-MOP) was used to briefly provide free psoralen sufficient for marked cutaneous photosensitization, but only a small dose of UVA was delivered initially, in an effort to produce many monoadducts but few crosslinks. After ample time for clearance of the remaining free

[In vitro study of emulsions containing methoxsalen].

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Vitiligo is an acute disease of skin with inflammation which means damage of melanocites, their defined partial paint lack. It is a frequent sickness which is very conspicuous and disturbing illness. For its treatment, systematically and topically psoralen-derivatives, UV-A radiation and other

Effect of oral methoxsalen photochemotherapy on human Langerhans cell number. Dose-response and time-sequence studies.

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In human adult volunteers, oral 8-methoxypsoralen and UVA (PUVA) caused an almost linear dose-response effect in depleting adenosine 1--5 J/cm2 were used. A higher dose did not appreciably augment the LC depleting effect although the intensity of the PUVA-induced skin inflammation increased. After a

Low-fluence carbon dioxide laser irradiation of lentigines.

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Low-fluence carbon dioxide (CO2) laser irradiation of skin has previously been shown to induce damage limited primarily to the epidermis. To evaluate whether this technique was therapeutically effective for pigmented epidermal lesions, ten lentigines caused by methoxsalen and ultraviolet light

A case of chronic GVHD following bone marrow transplantation from a phenotypically HLA-matched unrelated donor.

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A 45-year-old male with chronic myelocytic leukemia who received a bone marrow transplantation from a phenotypically HLA-matched unrelated donor developed chronic GVHD on day 100 post transplantation. He developed a slight fever, malaise, hepatic dysfunction and extensive itchy erythema with scaling

Pustulosis vegetans.

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Sterile pustules and crusted vegetative plaques on the trunk and limbs developed in a 24-year-old man. They left cribriform scars after healing. Histologically, the lesions showed epidermal proliferation and pustulosis resembling that found in "pyoderma vegetans" and pemphigus vegetans. The lesions

Long-term application of extracorporeal photochemotherapy in severe atopic dermatitis.

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BACKGROUND Extracorporeal photochemotherapy (ECP) using UVA irradiation of enriched leukocytes in the presence of methoxsalen as a photoactivatable substrate has been employed for the treatment of several immunologically mediated disorders. OBJECTIVE Our purpose was to determine the efficacy and

The effects of psoralen and UVA (PUVA) on epidermal melanocytes of the tail in C57BL mice.

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The morphological and numerical changes in epidermal melanocytes in tail skin of C57BL mice after exposure to psoralen followed by UVA irradiation were studied. The dorsal aspect of the tail was painted daily for 5 days a week with 0.1 ml methoxsalen (8-methoxypsoralen) in acetone, followed by UVA

Toxicology and Carcinogenesis Studies of 8-Methoxypsoralen (CAS No. 298-81-7) in F344/N Rats (Gavage Studies).

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Oral administration of 8-methoxypsoralen followed by exposure to longwave ultraviolet light (primarily ultraviolet A, 320-400 nm) is used in the treatment of vitiligo and psoriasis. 8-Methoxypsoralen also occurs naturally in a variety of vegetables. Toxicology and carcinogenesis studies of

Nitric Oxide Mediated Degradation of CYP2A6 via the Ubiquitin-Proteasome Pathway in Human Hepatoma Cells.

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Several cytochrome P450 enzymes are known to be down regulated by nitric oxide (NO). CYP2A6 is responsible for the metabolism of nicotine and several other xenobiotics, but its susceptibility to down-regulation by NO has not been reported. To address this question, we used HuH7 human hepatoma cell

Botanicals in dermatology: an evidence-based review.

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Botanical extracts and single compounds are increasingly used in cosmetics but also in over-the-counter drugs and food supplements. The focus of the present review is on controlled clinical trials with botanicals in the treatment of acne, inflammatory skin diseases, skin infections, UV-induced skin

Photopheresis. Therapeutic potential in preventing restenosis after percutaneous transluminal coronary angioplasty.

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Photopheresis (extracorporeal photochemotherapy) is an immunomodulatory therapy that entails the reinfusion of peripheral blood mononuclear cells after exposure to the photoreactive agent methoxsalen and ultraviolet A (UVA) radiation. Currently available at approximately 150 treatment centers

Extracorporeal photopheresis (ECP) in patients with steroid-dependent Crohn's disease: an open-label, multicenter, prospective trial.

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BACKGROUND Extracorporeal photopheresis (ECP) involves ex vivo leukocyte treatment with methoxsalen and UVA light to generate a tolerogenic response. A previous trial demonstrated that ECP permits corticosteroid withdrawal in steroid-dependent Crohn's disease (CD) patients who were in clinical

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