Growth hormone or Placebo 0.1 mg/day self-administrated once a day.

Polycystic Ovary Syndrome

Nutropin 0.1 mg/day self-administered once a day

Nutropin

Information for women about polycystic ovary syndrome from the American Academy of Family Physicians.

Oregon Health and Science University

Low Dose Growth Hormone in Obese PCOS Women

Effects of Low Dose Growth Hormone (GH) Therapy on Insulin Sensitivity, Metabolic Profile, Adipocyte IGF-I and Insulin Signaling, Intramyocellular Lipids, and Cortisol Metabolism in Obese Women With Polycystic Ovary Syndrome (PCOS)

Kevin Yuen

Associate Professor in Endocrinology

450 mg of carbidopa per day for four weeks followed by 75 mg of carbidopa per day for four weeks

75 mg of carbidopa per day for four weeks followed by 450 mg of carbidopa per day

75 mg of carbidopa per day for four weeks followed by 450 mg of carbidopa per day for four weeks

Low Carbidopa Followed by High Carbidopa

High Carbidopa Followed by Low Carbidopa

Total

Sex: Female, Male

Tapping speed is an index of bradykinesia and is used as a response to levodopa infusion.
Reported as increase over average of three measurements between 8 AM and 9 AM (baseline tapping speed) as (taps/min)*(hours) for tapping scores from beginning of levodopa infusion to 3 hours after conclusion of levodopa infusion.

Day 1 of levodopa infusions following 4 weeks of low-dose carbidopa (75 mg/day). Carbidopa 25 mg administered at 8 AM, 10 AM and 12 PM for day 1 infusion.

Low-dose Carbidopa (75 mg/Day) Day 1

Day 2 of levodopa infusions following 4 weeks of low-dose carbidopa (75 mg/day). Carbidopa 25 mg administered at 8 AM, 10 AM, and 12 PM for day 2 infusion.

Low-dose Carbidopa (75 mg/Day) Day 2

Day 1 of levodopa infusions following 4 weeks of high-dose carbidopa (450 mg/day). Carbidopa 25 mg administered at 8 AM 10 AM and 12 PM for day 1 infusion.

High-dose Carbidopa (450 mg/Day) Day 1

Day 2 of levodopa infusions following 4 weeks of high-dose carbidopa (450 mg/day). Carbidopa 150 mg administered at 8 AM, 10 AM and 12 PM for day 2 levodopa infusion.

High-dose Carbidopa (450 mg/Day) Day 2

Area Under the Curve (AUC) of Tapping Speed

Baseline value is levodopa concentration at 9 AM. AUC is calculated as levodopa concentrations minus 9 AM value at 30 minute intervals until 2 PM.

Day 1 of levodopa infusions following 4 weeks of high-dose carbidopa (450 mg/day). Carbidopa 25 mg administered at 8 AM, 10 AM and 12 PM for day 1 infusion.

Day 2 of levodopa infusions following 4 weeks of low-dose carbidopa (75 mg/day). Carbidopa administered at 8 AM, 10 AM and 12 PM for day 2 infusion.

Day 2 of levodopa infusions following 4 weeks of high-dose carbidopa (450 mg/day). Carbidopa 150 mg administered at 8 AM, 10 AM and 12 PM on day 2.

AUC of Levodopa Plasma Concentrations Above Baseline

Overall Study

John G. Nutt, MD

Due to the cross-over study design all 12 participants who completed the study are included in both the high-dose and low-dose treatment arms.

Low-dose Carbidopa (75 mg/Day)

Due to the cross-over study design all 12 participants who completed the study are included in both the high-dose and low-dose treatment arms. In addition, the subject who initiated treatment but did not complete the study is included in this arm for the purpose of reporting adverse events.

High-dose Carbidopa (450 mg/Day)

Parkinson's Disease

75 mg of carbidopa per day versus 450 mg of carbidopa per day

oregon/албумин

Low Dose Growth Hormone in Obese PCOS Women

High and Low Dose Carbidopa Treatment of Parkinson's Disease

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