The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R.sub.1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R.sub.2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR.sub.4R.sub.5, --NHC(.dbd.Y)R.sub.4, --NHC(.dbd.Y)NR.sub.5R.sub..chi., --NHC(.dbd.O)OR.sub.4, --NHSO.sub.2R.sub.4, C(.dbd.Y)NR.sub.4R.sub.5, C(.dbd.O)OR.sub.6 [wherein Y is oxygen or sulphur], OR.sub.5, --O(C.dbd.O)NR.sub.4R.sub.5, O-acyl, S(O).sub.mR.sub.4, --SO.sub.2N(R.sub.4).sub.2, cyano, amidino or guanidino [wherein R.sub.4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R.sub.5 is hydrogen or R.sub.4; R.sub.x is R.sub.4 or --SO.sub.2N(R.sub.4).sub.2 and R.sub.6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R.sub.3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR.sub.4, --OC(.dbd.O)NR.sub.4R.sub.5, O-acyl, NH.sub.2, NR.sub.4R.sub.5, --NHC(.dbd.Y)R.sub.4, --NHC(.dbd.Y)NR.sub.5R.sub.x, --NHC(.dbd.O)OR.sub.4, --NHSO.sub.2R.sub.4, and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of an matrix metalloproteinase, using the compounds. ##STR00001##

Palle; Venkata P.

Sattigeri; Viswajanani Jitendra

Khera; Manoj Kumar

Voleti; Sreedhara Rao

Ray; Abhijit

Dastidar; Sunanda G.

Ranbaxy Laboratories Limited

5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases

pentanoic acid

рак

neoplasms

pentanoic acid/рак

5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases

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