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Cardiovascular disease (CVD) is the largest cause of global mortality accounting for over twenty-nine percent of all deaths with coronary heart disease and stroke projected to become the global leading causes of mortality by 2020. Increased mortality represents only one side of the problem since the
Background
WARFARIN AND THE MONITORING OF ANTICOAGULATION THERAPY: Warfarin, an oral anticoagulant medication which disrupts vitamin K's ability to activate clotting factors in the liver, has strong evidence for efficacy in the prevention of thromboembolic disease (most notably in the setting of
AIM: To determine if betaine is a modulator of FGF21 in humans. Low plasma betaine is associated with an increased risk of metabolic syndrome, but the mechanisms modulating this correlation are poorly delineated. Betaine bioavailability in humans is determined by dietary intake and genetic