tendinopathy/seizures

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Is Mr Pac Man eating our children? A review of the effect of video games on children.

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OBJECTIVE To provide mental health professionals with an up-to-date review of the literature regarding the effects of playing video games on the well-being of children. METHODS A computerized literature search of MEDLINE and PSYCHINFO of all articles written in English from 1966 to 1996 was

Safety concerns with fluoroquinolones.

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OBJECTIVE To review the chemistry, pharmacology, and safety of fluoroquinolones. METHODS A MEDLINE search (1966-July 2007) was conducted using the key words fluoroquinolones or quinolones with safety, adverse effects, hypoglycemia, hyperglycemia, dysglycemia, QTc prolongation, torsades, seizures,

[Levofloxacin adverse effects, data from clinical trials and pharmacovigilance].

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With 5388 patients in the marketing application dossiers and post-marketing experience of more than 130 million prescriptions of levofloxacin worldwide, the tolerability profile of this anti-infective is now well defined. During clinical trials, 12 per cent of patients treated with levofloxacin

Tolerability of fluoroquinolone antibiotics. Past, present and future.

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New fluoroquinolones have been in clinical use for 10 years and have an excellent record of safety and tolerance. The main elements of their adverse reaction profile were predictable from human experience with precursor naphthyridines and quinolones, and from toxicological studies in animals. Thus

Levofloxacin-induced tactile hallucination and acute anxiety reaction.

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Fluoroquinolones are the commonly used antimicrobials in the treatment of urinary tract infection, bacterial diarrhea, and infections of soft tissue, bone, and joints. They may cause adverse effects ranging from gastrointestinal disturbances, headache, insomnia, and cutaneous reactions. Their rare

A risk-benefit assessment of levofloxacin in respiratory, skin and skin structure, and urinary tract infections.

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As a class, the quinolone antibacterials can no longer be assumed to be both effective and relatively free of significant adverse effects. Recent safety issues with newer generation fluoroquinolones, and concerns regarding drug-use associated bacterial resistance have made all drugs in this class

Comparative tolerability of the newer fluoroquinolone antibacterials.

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The most common adverse effects of the fluoroquinolones involve the gastrointestinal tract, skin and CNS, and are mainly mild and reversible. Of the gastrointestinal events, nausea and vomiting are the most common. Mild hepatic reactions are a class effect, usually presenting as mild transaminase

A comparison of ciprofloxacin, norfloxacin, ofloxacin, azithromycin and cefixime examined by observational cohort studies.

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1. The safety in everyday clinical usage of three 4-quinolone antibiotics, (ciprofloxacin, norfloxacin and ofloxacin), was compared with similar data for azithromycin and cefixime, each agent being examined by Prescription-Event Monitoring (PEM) during the early post-marketing period. 2. In PEM the

Antimicrobial safety: focus on fluoroquinolones.

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OBJECTIVE Infrequent toxicities associated with certain drugs and drug classes have recently gained much attention from different health-care perspectives. To protect the patient, continued surveillance of safety and tolerability data is essential. Data from preclinical testing, phase 1-3 trials,

Safety considerations of fluoroquinolones in the elderly: an update.

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The fluoroquinolones ciprofloxacin, levofloxacin, moxifloxacin and gemifloxacin are widely used for the treatment of various types of bacterial infections. Overall, these antibacterial agents can be considered safe and well tolerated drugs. Comparative studies have evaluated the use of quinolones in

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