Patients will receive standard care with the addition of NO gas. During cardiopulmonary bypass, NO at 20 ppm will be added to the sweep gas of the extracorporeal circuit. Following termination of cardiopulmonary bypass, inhaled NO will be discontinued.

Placebo delivery of oxygen at standard dose.

Patients will receive standard care with the addition of NO gas. During cardiopulmonary bypass, NO at 20 ppm will be added to the sweep gas of the extracorporeal circuit. Following termination of cardiopulmonary bypass, inhaled NO will be discontinued.
Nitric Oxide : Patients will receive standard care with the addition of NO gas. During cardiopulmonary bypass, NO at 20 ppm will be added to the sweep gas of the extracorporeal circuit. Following termination of cardiopulmonary bypass, inhaled NO will be discontinued.

1 Treatment

2 Placebo

Total

Sex: Female, Male

Region of Enrollment

Inflammation measured through the measurement inflammatory mediators, serum interleukin-6, serum interleukin-8, and tumor necrosis factor. Baseline (preoperative, 0h, 12h, 24h, and 48h.

Patients will receive standard care with the addition of NO gas. During cardiopulmonary bypass, NO at 20 ppm will be added to the sweep gas of the extracorporeal circuit. Following termination of cardiopulmonary bypass, inhaled NO will be discontinued.
Nitric Oxide: Patients will receive standard care with the addition of NO gas. During cardiopulmonary bypass, NO at 20 ppm will be added to the sweep gas of the extracorporeal circuit. Following termination of cardiopulmonary bypass, inhaled NO will be discontinued.

Nitric Oxide Delivery Group

Placebo

Serum Inflammatory Mediators Post CPB

Troponin levels correlate with myocardial injury. Greater troponin levels represent greater myocardial injury

Myocardial Injury

BNP levels correlate to ventricular and myocardial performance, function, and strain. Higher values represent greater strain and decreased function.

Myocardial Function as Measured by B-type Natiuretic Peptide (BNP) Levels

Lactate levels correlate to ischemic injury. Higher values represent more injury.

Ischemic Injury as Measured by Lactate Levels

Incidence of Methhemoglobin >5%, Gene Expression Profiles, and S100B.

Overall Study

Paul Checchia MD

Congenital Heart Disease

Nitric Oxide

St. Louis Children's Hospital

Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass

A Trial of Inhaled Nitric Oxide (NO) as an Anti-Inflammatory and Anti-Reperfusion Agent in the Treatment of Infants and Children Undergoing Cardiopulmonary Bypass for Repair of Congenital Heart Disease

tetralogy of fallot/треска

Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass

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