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visceral pain/повраќање

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Sulphonamide derivatives, their preparation and their therapeutic application

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FIELD OF THE INVENTION The present invention relates to sulfonamide derivatives, to the process for preparing them and to their therapeutic use. BACKGROUND OF THE INVENTION Orexins A and B (or hypocretins 1 and 2) are hypothalamus neuropeptides of 33 and 28 amino acids, respectively, recently

Substituted 1-piperidin-3-yl-4-piperidin-4-yl-piperazine derivatives and their use as neurokinin antagonists

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CROSS REFERENCE TO RELATED APPLICATIONS This application is the national stage of Application No. PCT/EP2003/051035, filed 17 Dec. 2003, which application claims priority from PCTEP2002/14835 filed 23 Dec. 2002, which are hereby incorporated by reference. FIELD OF THE INVENTION This invention

Benzimidazolone derivatives as CB2 receptor ligands

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BACKGROUND OF THE INVENTION This invention relates to benzimidazolone derivatives. These compounds have selective cannabinoid(CB)2 receptor binding activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives for the

Sulfonyl benzimidazole derivatives

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BACKGROUND OF THE INVENTION This invention relates to sulfonyl benzimidazole derivatives. These compounds have selective cannabinoid (CB)2 receptor agonistic activity. The present invention also relates to a pharmaceutical composition, method of treatment and use, comprising the above derivatives

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Meso-azacyclic amides of certain bicyclic carboxylic acids

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

New meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof as pharmaceuticals

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

Meso-azacyclic aromatic acid amides and esters as novel serotonergic agents

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt

New meso-azacyclic aromatic acid amides and esters as novel serotonergic agents

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BACKGROUND OF THE INVENTION The invention herein is directed to compounds and a method of treating gastrointestinal motility disorders of a mammal by administering to the mammal in need thereof a therapeutically effective amount of a compound disclosed herein or a pharmaceutically acceptable salt
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