Irritable Bowel Syndrome (IBS)

ONO-2952

Placebo comparator

Boston Clinical Site

St. Louis Clinical Site

Chapel Hill Clinical Site

Oklahoma City Clinical Site

Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)

A Phase 2, Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) (RESTORE)

Ono Pharma USA Inc

Irritable Bowel Syndrome

Iyengar yoga

UCLA Pediatric Pain Program

Iyengar Yoga for Young People With Irritable Bowel Syndrome

University of California, Los Angeles

Chronic Pancreatitis

Pregabalin

placebo

Department of Gastroenterology, Aalborg Hospital

Department of Suregery, Radboud University Nijmegen Medical Centre

Pain and Chronic Pancreatitis - Clinical End Experimental Studies

A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Clinical and Experimental Pilot Study of Pregabalin in Patients With Chronic Pancreatitis

The primary efficacy parameter to be evaluated is pain relief assessed using a patient pain diary based on the visual analog scale (VAS). Furthermore different questionnaires, including the modified brief pain inventory-short form (mBPI-sf), the painDETECT questionnaire (PD-Q) and patient global impression of change (PGIC)will be used to explore further aspects of pain character and influence on cognitive and affective components.

Secondary efficacy parameters are changes in quality of life compared to baseline level. The European Organization for research and treatment of cancer quality of life questionnaire (EORTC QOL-C30).Also the tolerability of the drug in this patient population will be compared to placebo.

visceral pain/пролив

Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)

Iyengar Yoga for Young People With Irritable Bowel Syndrome

Pain and Chronic Pancreatitis - Clinical End Experimental Studies

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