Effect of Fermented Maillard Reacted Whey Protein on Immune Function
Түлхүүр үгс
Хураангуй
Тодорхойлолт
A randomized, double-blind, placebo-controlled study was conducted on 80 participant without diabetes and obesity. Over a 8-week testing period, the F-MRP group consumed 6 g of powder containing 4.2 g F-MRP each day, whereas the placebo group consumed the same amount with dextrin. NK cell activity (%) was measured based on the ratios of effector cells (E; peripheral blood mononuclear cells, PBMCs) from each participant to target cells (T; K562 cells) at E:T= 10:1, 5:1, 2.5:1, or 1.25:1.
Огноо
| Сүүлд баталгаажуулсан: | 08/31/2016 |
| Эхлээд оруулсан: | 08/29/2016 |
| Тооцоолсон элсэлтийг оруулсан: | 09/03/2016 |
| Эхлээд нийтэлсэн: | 09/08/2016 |
| Сүүлийн шинэчлэлтийг оруулсан: | 02/08/2017 |
| Сүүлийн шинэчлэлтийг нийтэлсэн: | 02/12/2017 |
| Сургалтын бодит эхлэх огноо: | 09/30/2015 |
| Тооцоолсон анхан шатны ажил дуусах огноо: | 05/31/2016 |
| Судалгааны ажлыг дуусгах өдөр: | 05/31/2016 |
Нөхцөл байдал эсвэл өвчин
Хөндлөнгийн оролцоо / эмчилгээ
Dietary Supplement: Test group (F-MRP)
Dietary Supplement: Placebo group
Үе шат
Arm Groups
| Гар | Хөндлөнгийн оролцоо / эмчилгээ |
|---|---|
| Experimental: Test group (F-MRP) Fermented Maillard reacted whey protein (F-MRP) supplementation | Dietary Supplement: Test group (F-MRP) 6g of powder containing 4.2g fermented maillard reacted whey protein |
| Placebo Comparator: Placebo group Placebo supplementation | Dietary Supplement: Placebo group 6g of maltodextrin |
Эрхийн шалгуур
| Суралцах боломжтой нас | 20 Years Хэнд 20 Years |
| Суралцах боломжтой хүйс | All |
| Эрүүл сайн дурын ажилтнуудыг хүлээн авдаг | Тийм ээ |
| Шалгуур үзүүлэлтүүд | Inclusion Criteria: - Able to give informed consent - The levels of white blood cells within range 3x10^3/μL~8x10^3/μL - Males and females - 20-70 years old - Without no severe complications Exclusion Criteria: - Diabetes - White blood cell under 3x10^3/μL or over 8x10^3/μL - Pregnancy or breast-feeding - Hypersensitivity or disease history for milk protein - Liver disease, inflammation disease, or severe kidney failure disease - Cancer, lung disease, leukemia, or autoimmune disease - Psychological or neurological disease - Myocardiac infarction or cerebrovascular diseases within 6 months before screening - Consumption of other test products or drugs within 1 month before screening - Inflammation related disease within 1 month before screening |
Үр дүн
Анхан шатны үр дүнгийн арга хэмжээ
1. Natural killer cell activity [At baseline]
2. Natural killer cell activity [At 8-week follow-up]
3. Change from baseline natural killer cell activity at 8-week [At baseline and 8-week follow-up]
Хоёрдогч үр дүнгийн арга хэмжээ
1. White blood cell [At baseline]
2. White blood cell [At 8-week follow-up]
3. Change from baseline white blood cell at 8-week [At baseline and 8-week follow-up]
4. Interleukin-12 [At baseline]
5. Interleukin-12 [At 8-week follow-up]
6. Change from baseline Interleukin-12 at 8-week [At baseline and 8-week follow-up]
7. Interferon-gamma [At baseline]
8. Interferon-gamma [At 8-week follow-up]
9. Change from baseline Interferon-gamma at 8-week [At baseline and 8-week follow-up]
