Kidney Injury Severity and COVID-19
Түлхүүр үгс
Хураангуй
Тодорхойлолт
In December 2019, an outbreak of the 2019 novel coronavirus disease (COVID-19) caused by the SARS coronavirus 2 (SARS-CoV-2) occurred in Wuhan, China. It has spread rapidly to other areas in China and worldwide. The most common manifestations of COVID-19 included fever, dry cough, dyspnea, myalgia, fatigue and radiographic evidence of pneumonia. Complications (acute respiratory distress syndrome, shock, acute cardiac injury, secondary infection, and acute kidney injury) and death may occur in severe cases. Recent reports showed that extrapulmonary symptoms (intestinal symptoms in 10-20% of patients) and renal failure in some patients may be associated with the interaction of the virus with angiotensin-converting enzyme 2 (ACE-2) receptors in other organs. It was suggested that ACE-2 expression in the kidneys can be the cause of kidney injury occurring in a number of patients with SARS-CoV-2.However, ACE-2 is not the only possible cause of kidney injury - sepsis-related cytokine storm can also lead to damage of kidney parenchyma.
The present study aims to explain the mechanisms of kidney injury in patients diagnosed with COVID-19.
Огноо
| Сүүлд баталгаажуулсан: | 06/30/2020 |
| Эхлээд оруулсан: | 05/10/2020 |
| Тооцоолсон элсэлтийг оруулсан: | 05/10/2020 |
| Эхлээд нийтэлсэн: | 05/12/2020 |
| Сүүлийн шинэчлэлтийг оруулсан: | 07/26/2020 |
| Сүүлийн шинэчлэлтийг нийтэлсэн: | 07/27/2020 |
| Сургалтын бодит эхлэх огноо: | 05/14/2020 |
| Тооцоолсон анхан шатны ажил дуусах огноо: | 10/14/2020 |
| Судалгааны ажлыг дуусгах өдөр: | 11/14/2020 |
Нөхцөл байдал эсвэл өвчин
Хөндлөнгийн оролцоо / эмчилгээ
Diagnostic Test: mRNA in urine test
Үе шат
Arm Groups
| Гар | Хөндлөнгийн оролцоо / эмчилгээ |
|---|---|
| Mild COVID-19 Pneumonia without respiratory failure | |
| Moderate COVID-19 up to 60 years Respiratory frequency ≥30/minute, blood oxygen saturation≤93% | |
| Moderate COVID-19 over 60 years old and severe COVID-19 Pneumonia with respiratory distress syndrome |
Эрхийн шалгуур
| Суралцах боломжтой нас | 18 Years Хэнд 18 Years |
| Суралцах боломжтой хүйс | All |
| Дээж авах арга | Non-Probability Sample |
| Эрүүл сайн дурын ажилтнуудыг хүлээн авдаг | Тийм ээ |
| Шалгуур үзүүлэлтүүд | Inclusion Criteria: - Pneumonia confirmed by CT scans Exclusion Criteria: - a history of chronic renal failure; - a history of kidney transplantation; - intake of substances with a history of renal toxicity (no later than a month before inclusion); - patients with a single kidney; - refusal of the patient to participate in the study; - absence of SARS-CoV-2 virus smear from the nasopharynx in PCR. |
Үр дүн
Анхан шатны үр дүнгийн арга хэмжээ
1. The effect of COVID-19 severity on the severity of renal failure [2 months]
Хоёрдогч үр дүнгийн арга хэмжээ
1. The expression of viral RNA in the urine with the severity of renal failure [2 months]
2. The severity of microalbuminuria in patients with COVID-19 of different conditions and renal failure [2 months]
3. Assessment of the severity of renal impairment in patients who died from COVID-19 [2 months]
4. Estimation of the duration of urinary viral RNA isolation in patients undergoing COVID-19 [2 months]
5. Expression of ACE-2 receptors in the kidneys of patients with renal failure who died from COVID-19 [2 months]
