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Хуудас 1 -аас 294 үр дүн
7-Tert-butyl-3-(2-fluorophenyl)-6-(2H-(1,2,4)triazol-3-ylmethoxy)-(1,2,4)t- riazolo (4,3b) pyridazine for the treatment of anxiety and convulsions
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
CROSS REFERENCE TO RELATED APPLICATIONS
This application is a U.S. National Phase application under 35 U.S.C. .sctn.371 of PCT Application No. PCT/GB02/04201, filed Sep. 13, 2002, which claims priority under 35 U.S.C. .sctn.119 from GB Application No. 0122696.8, filed Sep. 20, 2001.
The present
Compositions and methods for uncoupling TrkB receptor from PLC gamma 1 for the treatment of epilepsy and anxiety-like disorder
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
FIELD OF THE INVENTION
The present disclosure relates generally to field of neurobiology. Specifically, the present disclosure relates to novel compositions and methods of modulating TrkB signaling and inhibiting TrkB-mediated activation of phospholipase C.gamma.1 (PLC.gamma.1) for the treatment of
Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
INTRODUCTION
I. Field of the Invention
The present invention relates to: cells and non-human animals deficient for the protein kinase C isozyme .epsilon. (PKC.epsilon.); the use of PKC.epsilon. as a target for drugs; the use of modulators of PKC.epsilon. in methods of reducing anxiety, modulating
Protein kinase C epsilon as modulator of anxiety, alcohol consumption and self-administration of drugs of abuse
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
INTRODUCTION
FIELD OF THE INVENTION
The present invention relates to: cells and non-human animals deficient for the protein kinase C isozyme .epsilon. (PKC.epsilon.); the use of PKC.epsilon. as a target for drugs; the use of modulators of PKC.epsilon. in methods of reducing anxiety, modulating
Compositions and methods for treatment of neurological symptoms associated with alcohol-withdrawal and for convulsive seizure
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
FIELD OF THE INVENTION
Aspects of the present invention relate generally to alcohol withdrawal syndrome (AWS), and isoprenoid-based compounds, and more particularly to pharmaceutical compositions comprising calcium channel blockers (e.g., isoprenoids such as farnesol and/or farnesol analogues or
Imidazo[1,5-A]quinolines for treatment of anxiety and sleep disorders
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is to imidazo[1,5-a]quinolines which are useful pharmaceutical agents for the treatment of anxiety, sleep disorders, panic states, convulsions and muscle disorders.
2. Description of the Related Art
EP 283,162 discloses
Cyclohexylamine derivatives as subtype selective N-Methyl-D-Aspartate antagonists
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
FIELD OF THE INVENTION
The invention provides cyclohexylamine derivatives as N-Methyl-D-Aspartate (NMDA) antagonists, pharmacological compositions comprising the derivatives, and methods of treating diseases and disorders responsive to antagonism of NMDA receptors using the derivatives.
BACKGROUND
CDNA encoding the human .alpha.2 .delta.4 calcium channel subunit
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
Voltage gated calcium channels (VGCC) mediate Ca.sup.2+ entry into cells in response to membrane depolarization (Catterall, W. A.(1988) Science 242:50-61 and Bean B P. (1989) Annu. Rev. Physiol. 51:367-368). Ca.sup.2+ entering the cell through voltage-gated Ca.sup.2+ channels serves as the second
Substituted 2,3-benzodiazepin-4-ones and the use thereof
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
This application claims benefit of U.S. provisional application Ser. No. 60/013,813 filed Mar. 21, 1996.
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention is in the field of medicinal chemistry. In particular, the invention relates to novel substituted 2,3-benzodiazepin-4-ones.
Pharmaceutical compositions comprising midazolam in a high concentration
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
FIELD OF THE INVENTION
The present invention relates to the administration of benzodiazepines such as midazolam. In particular, the invention provides improved midazolam compositions for intranasal administration comprising high concentrations of midazolam.
DISCUSSION OF THE PRIOR ART
Midazolam is a
Treatments involving eslicarbazepine acetate or eslicarbazepine
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
FIELD OF THE INVENTION
The invention relates to new therapeutic techniques involving eslicarbazepine acetate or eslicarbazepine.
BACKGROUND OF THE INVENTION
An epileptic seizure is defined as a clinical event associated with a transient, hypersynchronous neuronal discharge. The seizure represents
4-heteroaryl-1,3-benzodiazepines and 2-substituted-.alpha.-(heteroaryl)benzeneethanamines
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
This invention relates to 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines. More particularly, this invention relates to 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines of the formula: ##STR1## wherein Ar is a radical selected from the group consisting of ##STR2## wherein R.sup.2 is hydrogen,
4-heteroaryl-1,3-benzodiazepines and 2-substituted-gamma-(heteroaryl)benzeneethanamines
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
This invention relates to 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines. More particularly, this invention relates to 4,5-dihydro-4-heteroaryl-3H-1,3-benzodiazepines of the formula: ##STR1## wherein Ar is a radical selected from the group consisting of ##STR2## wherein R.sup.2 is hydrogen,
Phenyl carbamate compound and a composition for preventing or treating a psychiatric disorder comprising the same
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
BACKGROUND OF THE INVENTION
Field of the Invention
The present invention relates to a composition for preventing or treating a psychiatric disorder comprising a phenyl carbamate compound and a method for preventing or treating a psychiatric disorder therewith.
Description of the Related
Triazolo-pyrimidine as ligands for GABA receptors
Зөвхөн бүртгэлтэй хэрэглэгчид л нийтлэл орчуулах боломжтой
Нэвтрэх / Бүртгүүлэх
This is an application under 35 U.S.C. 371 of PCT/GB99/01827 and claims priority from Great Britain Application No. 9813006.5, filed Jun. 16, 1998.
BACKGROUND
The present invention relates to a class of substituted triazolo-pyrimidine derivatives and to their use in therapy. More particularly, this
Шинжлэх ухаанаар баталгаажсан эмийн өвс ургамлын бүрэн мэдээллийн сан
- 55 хэл дээр ажилладаг
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- Ургамлыг дүрсээр таних
- Интерактив GPS газрын зураг - эмийн ургамлыг байршлаар нь тэмдэглэнэ (удахгүй)
- Хайлттай холбоотой шинжлэх ухааны нийтлэлүүдийг уншина уу
- Эмийн өвсийг үр нөлөөгөөр нь хайж олох
- Мэдээллийн судалгаа, клиник туршилт, патентыг цаг тухайд нь сонирхож, зохион байгуул
Шинж тэмдэг эсвэл өвчний талаар бичиж, тус болох ургамлын талаар уншиж, өвслөг ургамлыг бичиж, өвчний эсрэг шинж тэмдгийг үзээрэй.
* Бүх мэдээлэл нь хэвлэгдсэн эрдэм шинжилгээний судалгаанд үндэслэсэн болно
