After retrofilling of teeth with MTA , defect was covered with collagen resorbable membrane.
healiguide collagen type 1 resorbable membrane covering the defect by extending 2-3 mm in every direction.

After retrofilling of teeth with MTA, flap was closed without application of collagen resorbable membrane.

Periapical Lesions

Resorbable membrane

after removing pathology and retro-filling the tooth /teeth wit MTA the defect area is left as it is and flap is closed without resorbable membrane.

periapical surgery without membrane

Guided Tissue Regeneration in the Healing of Through and Through Lesions

Effects of Guided Tissue Regeneration on the Healing of Through & Through Periradicular Lesions: A Randomized Controlled Study

Healing of the lesion will be checked at 3 months interval up to 1 year with the help of software CDR DICOM. At the end of 1 year this reduction in the pathology of lesion will be categorized as complete, incomplete, uncertain, unsatisfactory.
Clinical and radiographic examinations will be performed every 3, 6 and 12 months by assessing the same parameters as baseline except that PD, CAL, and GMP will not measured until 12 months.
Radiographic evaluations Jig radiographs will be taken at 3, 6 and 12th month of follow up.

At the end of 1 year clinical attachment level will be checked of involved teeth.

At the end of 1 year probing depth and will be checked of involved teeth.

Postgraduate Institute of Dental Sciences Rohtak

A total number of 15 patients in each group were selected. Patients were randomly allocated by computer program into two group. Clinical and radiographic examinations were performed every 3, 6 and 12 months by assessing the same parameters as baseline except that PD, CAL, and GMP were measured until 12 months. Routine examination procedure were used to evaluate any evidence of signs and/or symptoms. Jig radiographs were taken at 3, 6 and 12th month of follow up. Inter and intra observation of data will be analyzed by distribution of data. Categorical data will be analyzed by chi square test. Regression analysis will be done to observe any association between independent and dependent variables. Interobserver/intraobserver reliability with cohen kappa analysis.

Both the participant and primary investigator are blinded in the study until whole surgical procedure is completed and before suturing the flap.

Patients in this arm is treated with allogenic bone graft to fill the bone defect created with medial open wedge high tibial osteotomy

Patients in this arm is treated with synthetic bone substitute(geneX®) to fill the bone defect created with medial open wedge high tibial osteotomy

Osteoarthritis, Knee

Allogenic bone graft

Patients in this arm is treated with synthetic bone substitute (geneX®) to fill the bone defect created with medial open wedge high tibial osteotomy

Synthetic bone substitute (geneX®)

Joint Reconstruction Center, Seoul National University Bundang Hospital

Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy

Outcome Comparison of Allogenic Cancellous Bone and a New Synthetic Bone Substitute (geneX®) in Filling the Bone Defect Created With Medial Open Wedge High Tibial Osteotomy

Pain on operation site is measured on a 0-to-10 visual analogue scale(VAS) and 5-point Likert scale (0.no pain, 1.slight pain, 2.moderate pain, 3.severe pain, 4.extreme pain).
Initial postoperative pain will be recorded on postoperative day 2. After discharge from hospital (on postoperative day 2, on average), patients will visit outpatient department on 2weeks, 6weeks, 3months, 6months, 12months after surgery and pain measurements on each visit will be recorded.

Preoperative hemoglobin level is measured when the patient is admitted to the hospital for surgery and postoperative level is measured on postoperative day 2. The differences between values will be calculated.

Total operation time is defined as the time interval between skin incision and deflation of tourniquet (thigh tourniquet used in the operation to provide bloodless surgical field). Measured in minutes.

As a proxy variable of bone healing status, whether the patient can bear weight on operated knee is measured on a 3 point scale (1.full weight bearing, 2.partial weight bearing, 3.no weight bearing)
Patients will visit outpatient department on 2weeks, 6weeks, 3months, 6months, 12months after surgery and weight bearing status on each visit will be recorded.

As a proxy variable of bone healing status, pain with weight bearing is measured on a 0-to-10 visual analogue scale(VAS) and 5-point Likert scale (0.no pain, 1.slight pain, 2.moderate pain, 3.severe pain, 4.extreme pain)
Patients will visit outpatient department on 2weeks, 6weeks, 3months, 6months, 12months after surgery and pain with weight bearing on each visit will be recorded.

Total amount of drainage (in milliliters) from indwelling drain located in operative site, until its removal.

Time required to fill the bone defect (from the start of processing either allogenic bone graft or synthetic bone substitute to completely finish filling the defect. Measured in seconds.

Two independent investigators assess the progression of bone healing status on X-rays and the agreement between investigators will be measured. Bone healing status is assessed based on 3 point scale. (1. union not achieved yet, 2. partial union achieved, 3. complete union achieved)
Patients will visit outpatient department on 2weeks, 6weeks, 3months, 6months, 12months after surgery and bone healing status on X-rays will be recorded on 3months, 6months and 12months after surgery.

Amount of transfusion during patient's hospital stay, if any, is measured in packs.

When an event of postoperative complication occurs, it is recorded with postoperative date.

calcium sulfate/hemorrhage

Guided Tissue Regeneration in the Healing of Through and Through Lesions

Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy

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