This invention relates to riluzole for use in the treatment or prevention of adverse effects associated with the administration of anticancer agents having neurotoxic effects, such as, for example, platinum salts, taxanes and periwinkle alkaloids.

Busserolles; Jerome

Alloui; Abdelkrim

Lazdunski; Michel

Eschalier; Alain

UNIVERSITE D'AUVERGNE CLERMONT I

Use of riluzole for treating or preventing the adverse effects of antineoplastic agents

This invention relates to a chemical process of producing an antitumor alkaloid. More particularly, it relates to a method of isolation of vinblastine from Catharanthus roseus, comprising the steps of: extracting C. roseus leaves with an acidified aqueous solution; raising the pH and extracting an alkaloid mixture with an organic solvent; chromatographing a solution of the alkaloid mixture over dextran and silica gel columns to obtain vinblastine containing fractions for isolation.

Harbor Branch Oceanographic Institution, Inc.

Process of isolating vinblastine from the plant catharanthis roseus

catharanthus trichophyllus

хорт хавдар

catharanthus

anticancer

catharanthus trichophyllus/хорт хавдар

Use of riluzole for treating or preventing the adverse effects of antineoplastic agents

Process of isolating vinblastine from the plant catharanthis roseus

Шинжлэх ухаанаар баталгаажсан эмийн өвс ургамлын бүрэн мэдээллийн сан