Acute Diverticulitis

Hospital Universitari Bellvitge

Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis

To detect which patients with acute diverticulitis recur

To correlate systemic inflammatory markers with acute diverticulitis recurrence.
* Systemic inflammatory markers include: A blood test with leukocyte count and formula, C-reactive protein, albumin, Neutrophil-Lymphocyte ratio calculation, Platelet-lymphocyte ratio calculation, lymphocyte-monocyte ratio calculatio, Modified Glasgow Prognostic score calculation.

To correlate faecal calprotectine with acute diverticulitis recurrence

To correlate local inflammatory markers with systemic inflammatory markers and recurrence.
*Local inflammatory markers come from colonic endoscopic samples taken in the colonoscopy at 2 months after the acute diverticulitis episode. 2 samples are taken:
Sample A: 1-5cm of diverticulum that has participated in diverticulitis episode (correlated with the CT)
Sample B: 30cm of the area that has suffered diverticulitis. Sampling for the study of local inflammatory markers includes IL-6, IL-10, tumour necrosis factor (TNF), macrophages, eosinophils and calculation of inflammation index of Ulcerative Colitis.

To correlate clinical symptoms with inflammatory markers.
Questionnaires used:
SF-12 Health Survey, in order to measure Mental and Physical Health. There are 8 areas with a minimum value of 0 (the worst health state) and a maximum of 100 (best health state)
GIQLI (Gastrointestinal Quality of Life questionnaire). Minimum value of 0 (the worst health state) and a maximum of 100 (best health state)

diverticulum/nicotine

Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis

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