Хуудас 1 -аас 161 үр дүн
The beneficial effects of pyruvate in organ reperfusion injury have been documented, however the therapeutic use of pyruvate has been hindered by the lack of an appropriate delivery method. Pyruvic acid is unstable and high rates of sodium pyruvate infusion are toxic. Dipyruvyl-acetyl-glycerol
Using our previously published "incomplete cerebral hemispheric infarction model in dogs" (produced by simultaneous ipsilateral occlusions of the anterior cerebral artery at the branching of the ethmoidal artery from its A1 portion, the A2 portion, the internal carotid artery, the posterior
Using our previously published "incomplete cerebral hemispheric infarction model in dogs" (produced by simultaneous, ipsilateral occlusion of the anterior cerebral artery at the branching of the ethmoidal artery from its A1 portion, the A2 portion, the internal carotid artery, the posterior
Intravenous administration of glycerol has been used in an effort to improve the prognosis for patients with acute cerebral infarction. Fifty patients were treated actively and 56 served as a control group. The neurological status before, during and after treatment for six days was assessed by a
Intravenous administration of glycerol under double-blind conditions (25 g twice daily for 6 days) to 26 patients with cerebral infarction localized in the territory of the middle cerebral artery temporarily improved the clinical evolution, as assessed by a scoring system, in comparison with 25
From a population of patients with acute cerebral infarction one hundred were selected and divided into two groups, with comparable neurological deficit and risk factors. To one group of patients glycerol was administered, the other group served as a control. Neurological deficit was scored on the
Administration of large amounts of levodopa did not improve survival rates of rats after acute cerebral infarction induced by injection of carbon microspheres. However, when 10% glycerol was used, the number of rats that survived after cerebral infarction was significantly greater than in the
10 percent glycerol was given for 6 days to 30 patients who had had acute ischaemic cerebral infarction, and the results were compared with those obtained after treating 31 similar patients with dexamethasone (16 mg. per 24 hours for 6 days). 1 patient treated with glycerol died of haemoglobinuria
Regional cerebral blood flow and its autoregulation after intravenous glycerol infusion have been studied in eight patients in the acute phase of cerebral infarction. Glycerol seems to improve the cerebral blood flow in the damaged region but does not seem to restore autoregulation.
OBJECTIVE
This clinical trial investigates the effectiveness of intravenous glycerol therapy in patients with acute cortical infarction in whom intracerebral hemorrhage was rigorously excluded.
METHODS
Within 48 hours of symptoms from their first ischemic stroke, 113 hospital inpatients were
We recently reported that myocardial phosphoinositide (PI) metabolism can be visualised by 1-[1-11C]-butyryl-2-palmitoyl-rac-glycerol (11C-DAG) in rats with myocardial infarction (MI). Angiotensin II, the receptors for which are expressed predominantly in infarcted areas with active fibrogenesis
Phosphoinositide turnover mediates the signaling of angiotensin II, which plays a pivotal role in ventricular remodeling after myocardial infarction (MI). We tested the hypothesis that phosphoinositide turnover can be visualized by 1-[1 -(11)C]butyryl-2-palmitoyl-rac-glycerol (11C-DAG) in both
Heart tissue engineering is critical in the treatment of myocardial infarction, which may benefits from drug-releasing smart materials. In this work, we load a small molecule (3i-1000) in new biodegradable and conductive patches for application in infarcted myocardium. The composite patches consist
The effect of intravenous infusion of 10 per cent glycerol on regional cerebral blood flow (using hydrogen bolus and Xenon-133 (133Xe) clearance methods) and metabolism was investigated in 57 patients with recent cerebral infarction. Hemispheric blood flow (HBF) increased, together with increase in
Heart failure remains the leading cause of death in many industrialized nations owing to the inability of the myocardial tissue to regenerate. The main objective of this work was to develop a cardiac patch that is biocompatible and matches the mechanical properties of the heart muscle for myocardial