Patient given one 300mg St. John's Wort tablet three times per day

Patient given one 300mg St. John's Wort tablet three times per day
St. John's Wort: St. John's Wort 300mg tablet three times per day

St. John's Wort

Sex: Female, Male

Race/Ethnicity, Customized

Region of Enrollment

Primary objective was to assess the change in hot flashes over a four week period in patients given St. John's Wort

Effect of St. John's Wort on Hot Flash Frequency as Recorded in a Daily Hot Flash Diary From Baseline to 4 Weeks

The hot flash score is calculated as the frequency of hot flashes times the severity of the hot flashes averaged over a week.
Frequency is the number of hot flashes in a day. Severity is coded 0=None, 1=Mild, 2=Moderate, and 3=Severe. Score for each day is frequency times severity. Weekly score is averaged over seven days.
Score ranges from 0 to infinity
Lower scores are better.

Effect of St. John's Wort on Hot Flash Score as Recorded in a Daily Hot Flash Diary From Baseline to 4 Weeks

Toxicities are quantified using the standard NCI toxicity criteria. The outcome is the percentage of participants who experience one or more toxicities. More detailed information on toxicities is found in the adverse events section.

Estimation of Toxicities While on St. John's Wort

Quality of life was measured by the SF12 (MCS and PCS subscales). First we'll summarize the MCS.
SF-12 is the short form Health Survey (a short version of the SF-36) developed for the Medical Outcomes Study. It is managed by QualityMetric.
MCS is the mental health component of the SF-12. A normal population has a mean of 50 and a SD of 10. Higher numbers represent better mental health.
The range is 0 to 100.
Higher scores represent better mental health.

Effect of St. John's Wort on Quality of Life (MCS)

Quality of life was measured by the SF12 (MCS and PCS subscales). Now we'll summarize the PCS.
SF-12 is the short form Health Survey (a short version of the SF-36) developed for the Medical Outcomes Study. It is managed by QualityMetric.
PCS is the physical health component of the SF-12. Normal population has a mean of 50 and a SD of 10. Higher scores reflect better physical health.
The range is 0 to 100.
Higher scores represent better mental health.

Effect of St. John's Wort on Quality of Life (PCS)

POMS stands for the Profile of Mood States This is a short version of the POMS (17 questions).
Each question is scored on a 0 to 4 scale. The POMS score is the sum of the responses to the 17 questions. Responses to some questions have been reversed to make higher responses better.
The range is 0 to 68.
Higher scores represent better overall mood.

Patients given one 300mg St. John's Wort tablet three times per day
St. John's Wort: St. John's Wort 300mg tablet three times per day

Mood is Measured by the POMS Short Form.

Overall Study

Dr. Doug Case

Breast Cancer

Hot Flashes

St. John's Wort 300mg tablet three times per day

hypericum gentianoides/breast neoplasms

St. John's Wort in Relieving Hot Flashes in Postmenopausal Women With Non-Metastatic Breast Cancer

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