Intervention: hydrocortisone 1% ointment will be applied to one patient's forearm

Intervention: Oregano extract cream for mild to moderate atopic dermatitis will be applied to the other patient's forearm

Intervention: hydrocortisone 1% ointment will be applied to one patient's forearm
Hydrocortisone: An experimental cream will be applied to one of the arms of the patient which will be an oregano extract and will be compared to the standard treatment which will be hydrocortisone 1% ointment

Standard: Hydrocortisone 1% Ointment

Intervention: Oregano extract cream for mild to moderate atopic dermatitis will be applied to the other patient's forearm
Oregano extract cream: An experimental cream will be applied to one of the arms of the patient which will be an oregano extract and will be compared to the standard treatment which will be hydrocortisone 1% ointment

Experimental: Oregano Extract Cream

Total

Sex: Female, Male

Race (NIH/OMB)

This was measured with two questions. The first one referred to the description of the lesion and it included six characteristics: clear, dry, scaly, redness, cracks/opening and oozing. The second questions asked to grade how itchy was the patient.
All characteristics were measured on a scale from 0 to 5 (0 none, 5 extremely bothered/losing sleep).

The Clinical Efficacy Rated by the Patient or Caregiver on Days 0 and 25

Physician was asked to grade four characteristics: erythema, infiltration/papulation, excoriation and lichenification. The grade was none (0), mild (1), moderate (2) and severe (3).

Change of the Clinical Efficacy Rated by a Study Physician

Confocal microscopy was done to the patient on day 0, day 14 and day 28. Due to technical difficulties, this outcome measure was not collected.

Histological Improvement Measured by Confocal Microscopy

Bacterial culture of the affected area was done on day 0 and day 14.

Measure Presence of S. Aureus Colonization on Affected Skin

The patient or caregiver rated how the product felt on their skin after applying the product, measuring the cosmetic acceptability on day 7 and 14. The scale was excellent, good, moderate and poor.

Rate Cosmetic Acceptability of Topical Agents

The patient or caregiver rated how well the patient tolerated the product after applying it on day 7 and 14. The scale was excellent, good, moderate and poor.

Rate Skin Tolerance of Topical Agents

Overall Study

Amy Pappert, MD

Atopic Dermatitis

An experimental cream will be applied to one of the arms of the patient which will be an oregano extract and will be compared to the standard treatment which will be hydrocortisone 1% ointment

Oregano extract cream

Hydrocortisone

Department of Dermatology. Rutgers-RWJMS

Oregano Ointment vs. Standard Treatment for Pediatric Atopic Dermatitis

Investigator-Initiated, Randomized, Investigator-Blind, Half-Side Comparison of Topical Oregano Extract Ointment vs .Hydrocortisone 1% for the Treatment of Atopic Dermatitis in Pediatric Patients

oregano/үрэвслийн эсрэг

Oregano Ointment vs. Standard Treatment for Pediatric Atopic Dermatitis

Шинжлэх ухаанаар баталгаажсан эмийн өвс ургамлын бүрэн мэдээллийн сан