Succinylcholine 0.1 mg/kg will be administered and TOF ratio measured before and after the administration until stable

Succinylcholine 0.15 mg/kg will be administered and TOF ratio measured before and after the administration until stable

Succinylcholine 0.2 mg/kg will be administered and TOF ratio measured before and after the administration until stable

Succinylcholine 0.25 mg/kg will be administered and TOF ratio measured before and after the administration until stable

Succinylcholine 0.3 mg/kg will be administered and TOF ratio measured before and after the administration until stable

0.1 mg/kg of succinylcholine arm
Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.

Arm 1

0.15 mg/kg of succinycholine arm
Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.

Arm 2

0.2 mg/kg of succinylcholne arm
Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.

Arm 3

0.25 mg/kg succinylcholine arm
Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.

Arm 4

0.3 mg/kg succinylcholine arm
Succinylcholine: will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.

Arm 5

Total

Sex: Female, Male

We stimulated the ulnar nerve at the wrist four times (over 1.5 seconds) every 20 seconds. We measured the ratio of the fourth contraction to the first contraction before and after the administration of succinylcholine. Before administering succinylcholine the ratio is normally one. After the administration of succinylcholine the first contraction diminishes, but the fourth contraction diminishes even more. This results in a ratio of T4 to T1 being less than one. The lowest ratio recorded after the administration after the administration of succinylcholine is reported as our outcome measure.

Fade on Train of Four Stimulation

Overall Study

Shashi Bhatt, MD

Muscle Relaxants

will be administered succinylcholine in a dose of 0.1 mg/kg in Arm 1, 0.15 mg/kg in Arm 2, 0.2 mg/kg in Arm 3, 0.25 mg/kgin Arm 4, 0.3 mg/kg in Arm 5.

paraplegia/fever

Fade Upon TOF Stimulation Induced by Succinylcholine

Шинжлэх ухаанаар баталгаажсан эмийн өвс ургамлын бүрэн мэдээллийн сан