5 үр дүн
OBJECTIVE Painful neuropathic injuries induce blood-spinal cord barrier (BSCB) breakdown, allowing pro-inflammatory serum molecules to cross the BSCB, which contributes to nociception. The goal of these studies was to determine whether the blood-borne serine protease thrombin also crosses a
METHODS
Case report.
OBJECTIVE
To report a case of HIV-related lipodystrophy with a rapid onset of symptoms from epidural lipomatosis in the wake of protease inhibitor and steroid treatment.
BACKGROUND
Symptomatic spinal epidural lipomatosis is considered to be a rare condition usually presenting
Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the early upregulation of pro-inflammatory cytokines, the
Dorsal root injury is known to induce alteration of the extracellular environment in the spinal cord and synaptic reorganization with degradation of injured primary afferent and sprouting of spared terminal. These changes affect behavioral sensitivity and sometimes lead to neuropathic pain. We have
METHODS
A study of herniated lumbar disc tissue samples and control disc material to determine the presence of mast cells in disc herniations.
OBJECTIVE
To analyze whether mast cells have any involvement in disc herniation pathophysiology and lumbar pain, because mast cells may have an important