Хуудас 1 -аас 33 үр дүн
12 patients suffering from grass pollen hay fever were treated for 14 weeks pre- and co-seasonally by intranasal self-administration of an aqueous solution of a glutaraldehyde-treated timothy grass pollen allergen. These patients had a statistically significant decrease in nasal symptom scores
Grazax is a lyophilisate of an extract of Timothy-grass pollen (Phleum pratense) administered by the sublingual route to induce desensitization (or hyposensitization) to grass pollen in subjects with hay fever. Since allergen avoidance measures are limited in hay fever sufferers, present treatment,
BACKGROUND
IgE sensitization against grass pollen is a cause of seasonal allergic rhinitis.
OBJECTIVE
We sought to investigate the evolution at the molecular level and the preclinical predictive value of IgE responses against grass pollen.
METHODS
The German Multicentre Allergy Study examined a
IgE was removed from human basophils of 4 nonatopic persons and 10 hay fever patients allergic to timothy grass pollen by treating the cells with buffer adjusted to pH 4. IgE could be removed and refixed to the same cells. Refixation was demonstrated by immunofluorescence and by the ability of
BACKGROUND
Hay fever (allergic rhinoconjunctivitis) is a frequent disease and 12% of the Danish adult population suffer from grass-pollen induced hay fever. Symptomatic medication is the traditional treatment, while immunotherapy with sustained effect is an alternative. Grazax (Phleum pratense,
BACKGROUND
An early IgE response to grass or birch pollen can anticipate seasonal allergic rhinitis to pollen later in life or remain clinically silent.
OBJECTIVE
To identify risk factors early in life that allow discriminating pathogenic from non-pathogenic IgE responses and contribute to the
A simplified method for measuring basophil histamine release in grass pollen hay fever patients has been developed. Leukocytes were challenged in vitro with extracts of Phleum pratense (timothy) and the release of histamine was determined indirectly as the residual histamine in the cell sediment.
BACKGROUND
Farm children suffer less frequently from pollinosis and bronchial asthma, although they are exposed to higher concentrations of airborne allergens. How do farm children differ from children in the general population with respect to immunological sensitization to airborne
OBJECTIVE
To evaluate the efficacy and safety of immunotherapy (hyposensitisation) in patients with severe summer hay fever.
METHODS
A randomised, double blind, placebo controlled study of a biologically standardised depot grass pollen extract.
METHODS
Allergy clinic, Royal Brompton and National
In a double blind 3-year prospective study 40 grass pollen allergic patients were allocated to specific immunotherapy (hyposensitization) with two timothy major allergens, 19, 25, or partially purified timothy extract. The extracts were biologically standardized and coupled to aluminium hydroxide
Previous, placebo-controlled clinical trials with oral hyposensitization in grass pollinosis have been disappointing. Since the results possibly could be explained by too low doses of ingested allergens, the present study was initiated to evaluate the effect of high doses of allergens. Forty-two
This trial of hyposensitisation compares the efficacy and safety of an alum absorbed 2-grass extract (Phleum pratense and Dactylis glomerata) with a traditional pyridine extracted alum precipitated 5-grass preparation whose efficacy has been demonstrated previously. 33 patients, (20 Alpare, 13