Influence of Tobacco Use on Cannabis Use
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ToestandWerving
Sponsors
New York State Psychiatric Institute
Medewerkers
National Institute on Drug Abuse (NIDA)
KLINISCHE PROEF: NCT03766971
BioSeek: nct03766971
Sleutelwoorden
Abstract
Cannabis smokers who also smoke tobacco cigarettes have markedly higher rates of cannabis relapse relative to those who do not use tobacco. There is a clear need to develop and evaluate interventions for dual tobacco and cannabis users. The investigators of this study have previously shown that the co-use of tobacco cigarettes contributes to the maintenance of daily cannabis use, and that age of cigarette onset is a critical predictor of treatment outcome. Short-term tobacco cessation may suffice in altering cannabis relapse rates in later-onset cigarette smokers, while a longer period of tobacco cessation may be needed for earlier-onset smokers. In the current study, a human laboratory model will be utilized to determine whether cannabis relapse varies as a function of tobacco cessation duration and age of tobacco use onset.
Datums
| Laatst geverifieerd: | 01/31/2020 |
| Eerste ingediend: | 12/03/2018 |
| Geschatte inschrijving ingediend: | 12/04/2018 |
| Eerst geplaatst: | 12/05/2018 |
| Laatste update ingediend: | 02/18/2020 |
| Laatste update geplaatst: | 02/20/2020 |
| Werkelijke startdatum van het onderzoek: | 01/31/2020 |
| Geschatte primaire voltooiingsdatum: | 11/29/2024 |
| Geschatte voltooiingsdatum van het onderzoek: | 11/29/2024 |
Conditie of ziekte
Cannabis Use
Tobacco Use
Interventie / behandeling
Behavioral: 7 days of Tobacco Cessation
Behavioral: 21 days of Tobacco Cessation
Drug: Cannabis
Fase
Fase 2
Armgroepen
| Arm | Interventie / behandeling |
|---|---|
| Experimental: Early-onset Cigarette Smokers Participants who began smoking cigarettes earlier in life (<16 years old) will be randomized to 7 or 21 days of tobacco cessation. | |
| Experimental: Late-onset Cigarette Smokers Participants who began smoking cigarettes later in life (>16 years old) will be randomized to 7 or 21 days of tobacco cessation. |
Geschiktheidscriteria
| Leeftijden die in aanmerking komen voor studie | 18 Years Naar 18 Years |
| Geslachten die in aanmerking komen voor studie | All |
| Accepteert gezonde vrijwilligers | Ja |
| Criteria | Inclusion Criteria: - Males and non-pregnant females aged 18-60 years old - Use cannabis - Smoke tobacco cigarettes - Medically and psychologically healthy Exclusion Criteria: - Regular drug use other than cannabis - Current pregnancy/lactation |
Resultaat
Primaire uitkomstmaten
1. Cannabis self-administration [During 9-day inpatient phase]
Number of cannabis cigarettes participant chooses to smoke.
