Topical Vitamin C for Treatment of Basal Cell Cancer
Sleutelwoorden
Abstract
Omschrijving
Importance
Skin cancer is the most common cancer in the United States, with more people diagnosed each year than all other cancers combined (1). Basal cell cancer is the most common form with an estimated 4.3 million cases diagnosed annually (2,3). Costs of treating this cancer in the U.S. are estimated at $4.8 billion annually (4). Task force consensus guidelines suggest Mohs surgery as the treatment of choice, and as the single most precise and effective treatment method (5). However, cost and issues of cosmesis are principal disadvantages.
Objective
To evaluate efficacy of a therapeutic regimen in treating basal cell cancer, consisting of 30% ascorbic acid in 95% dimethylsulfoxide topically applied at home by patients twice a day for 8 weeks.
Design, Setting, and Participants
This case series of 4 patients with 6 lesions was conducted after biopsy proven diagnosis of basal cell cancer. All 4 patients sought initial non-surgical treatment. All 4 had an appointment set for Mohs surgery 10 wks after study enrollment, so in the event of treatment failure no further delay in definitive treatment would occur. Three patients were female, 1 male, and all were over the age of 50.
Interventions
An 8 wk therapeutic regimen of topical 30% (w/v) ascorbic acid, 95% (v/v) dimethylsulfoxide, and 5% (v/v) distilled water applied twice daily at home.
Main Outcomes and Measures
Number of lesions out of a total of six that were cancer free after 8 wks of treatment.
Datums
| Laatst geverifieerd: | 01/31/2020 |
| Eerste ingediend: | 02/18/2020 |
| Geschatte inschrijving ingediend: | 02/18/2020 |
| Eerst geplaatst: | 02/20/2020 |
| Laatste update ingediend: | 02/18/2020 |
| Laatste update geplaatst: | 02/20/2020 |
| Werkelijke startdatum van het onderzoek: | 02/28/2018 |
| Geschatte primaire voltooiingsdatum: | 02/28/2019 |
| Geschatte voltooiingsdatum van het onderzoek: | 05/31/2019 |
Conditie of ziekte
Interventie / behandeling
Drug: Treatment group
Fase
Armgroepen
| Arm | Interventie / behandeling |
|---|---|
| Experimental: Treatment group Participants applied topical solution of ascorbic acid twice daily for 8 weeks | Drug: Treatment group Twice daily application of 300 microliters of 30% ascorbic acid solution with a small cuticle brush. |
Geschiktheidscriteria
| Leeftijden die in aanmerking komen voor studie | 18 Years Naar 18 Years |
| Geslachten die in aanmerking komen voor studie | All |
| Accepteert gezonde vrijwilligers | Ja |
| Criteria | Inclusion Criteria: - Presence of biopsy proven basal cell carcinoma Exclusion Criteria: - Absence of basal cell carcinoma |
Resultaat
Primaire uitkomstmaten
1. Lesion Resolution [8 weeks]
