Journal of lipid mediators
Platelet-activating factor in Japanese cedar pollinosis.
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Abstract
The concentration of lyso-PAF in serum from untreated patients with Japanese cedar pollinosis, a typical allergic disease, was significantly higher than that in healthy controls. It was also found that the lyso-PAF level in serum from Japanese cedar pollinosis significantly decreased after therapy with ketotifen, an anti-allergic drug. These results suggest that PAF might play an important role in Japanese cedar pollinosis and that the clinical effect of anti-allergic drug might be partially due to the anti-PAF action.
