An N-containing five-membered ring compound of formula (I) ##STR1##wherein all symbols are the same as described in the specification, and a non-toxic salt thereof.The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation systems disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.

Ono Pharmaceutical Co., Ltd.

N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient

An N-containing five-membered ring compound of formula (I) ##STR00001## wherein all symbols are the same as described in the specification, and a non-toxic salt thereof. The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation systems disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.

A 1,3,4-oxadiazoline derivative of formula (I) ##STR1##wherein W is oxygen, sulfer; R is hydrogen, alkyl, CycA, etc.; AA.sup.1 is a single bond, amino acid residue, etc.; AA.sup.2 is a single bond, amino acid residue, etc.; R.sup.7 and R.sup.8 are hydrogen, alkyl, etc.; R.sup.9 is hydrogen, alkyl, etc., and a non-toxic salt thereof.The compound of formula (I) has an inhibitory activity against cysteine protease and therefore it is useful as an agent for the prophylaxis and/or treatment of inflammatory diseases, diseases induced by apoptosis, diseases induced by disorders of immune responses, autoimmune diseases, diseases induced by decomposition of proteins which compose organism, shock, circulatory system disorders, blood coagulation systems disorders, malignant tumors, acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC), parasitic diseases, nerve degeneration diseases, pulmonary disorders, bone resorption diseases, endocrinesthenia, etc.

aids-related complex/protease

N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient

N-containing five-membered ring compounds and pharmaceutical agents comprising the same as active ingredient

1,3,4-oxadiazoline derivative and an agent comprising its derivative as active ingredient

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