Aortic Valve Stenosis

Bassett Healthcare Network

Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis

Clinical Predictive Value of Podocan and Wnt Pathway Regulatory Molecules on Maladaptive Left Ventricular Response in Aortic Stenosis

All patients having a cardiac MRI have an IV line placed as normal procedure. When the line has been placed, prior to contrast infusion (if applicable)or other medication administration, blood samples will be collected to test for circulatory Podocan .

All patients having a cardiac MRI have an IV line placed as normal procedure. When the line has been placed, prior to contrast infusion (if applicable)or other medication administration, blood samples will be collected to test for circulatory Wnt pathway molecules

Any previously evaluated participants who go on to have aortic valve replacement surgery, will have repeat blood sampling for Podocan levels at time of 9-12 month post op assessment.

Any previously evaluated participants who go on to have aortic valve replacement surgery, will have repeat blood sampling for Wnt pathway molecule levels at time of 9-12 month post op assessment.

To assess whether circulatory podocan is associated with improved functional capacity of patients with AS, the relationship between circulatory podocan and a six minute walk test conducted at the time of cardiac MRI will be assessed

Daniel Katz

Attending Physician - Cardiology

Bassett Healthcare

Baylor University

The intervention group will be called EGHEM - Echo Guided HEmodyanmic Management - and will receive their intraoperative maintenance fluid and possible drug therapy (furosemide) based on their hourly intraoperative LVDD grade.

The control group will be
called SHEM - Standard HEmodynamic Management - and will NOT receive the study intervention, but will receive standard anesthesia and hemodynamic management based on current standards within the institution.

cardiomegaly/nicotine

Podocan and Wnt Pathway in Left Ventricular Remodeling of Aortic Stenosis

Echocardiography Management for Patients Requiring Care for Non-Cardiac Surgery

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