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14 resultaten
Secondary metabolites of Centaurea calolepis and evaluation of cnicin for anti-inflammatory, antioxidant, and cytotoxic activities.
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BACKGROUND
Centaurea L. (Astreaceae) species are used as herbal remedies in Turkey. Centaurea calolepis Boiss. is an endemic species of Anatolia that has not been subjected to phytochemical studies except essential oil analysis.
OBJECTIVE
Secondary metabolite determination, isolation and structure
Anti-inflammatory properties of Centaurea calolepis Boiss. and cnicin against Macrovipera lebetina obtusa (Dwigubsky, 1832) and Montivipera xanthina (Gray, 1849) venoms in rat.
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Macrovipera lebetina obtusa (Dwigubsky, 1832) and Montivipera xanthina (Gray, 1849) (Ottoman Viper) are viper snakes from Viperidae family and found in various locations in Anatolia. Both snakes are responsible for major snake bite cases in Turkey Their venoms cause necrosis, hemorrhage, pain and
Phytotoxic properties of cnicin, a sesquiterpene lactone fromcentaurea maculosa (spotted knapweed).
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Water and solvent extracts from the aerial tissues ofCentaurea maculosa, spotted knapweed, inhibited the root growth of lettuce. Column chromatography and lettuce bioassay of a chloroform extract led to the isolation of cnicin, a sesquiterpene lactone. Pure cnicin was bioassayed at 0, 1, 2, 4, 6, 8,
Biomimetic cyclization of cnicin to malacitanolide, a cytotoxic eudesmanolide from Centaurea malacitana.
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Malacitanolide (2), a new eudesmanolide isolated from the aerial parts of Centaurea malacitana, was characterized spectroscopically. The synthesis of 2 from cnicin (1), via the epoxide 3, confirmed the structure and stereochemistry of malacitanolide, as well as its biogenetic relationship with 1.
[Antibiotic and cytotoxic activity of cnicin isolated from Cnicus benedictus L].
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Sesquiterpene lactones from Centaurea zuccariniana and their antimicrobial activity.
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Twenty-nine compounds were isolated from the aerial parts of the Greek plant C. zuccariniana DC. The structures of the isolated compounds were established by means of NMR- ((1) H,(1) H-COSY, (1) H,(13) C-HSQC, HMBC, NOESY, and ROESY) and mass-spectral analyses. These compounds comprise 13
Sesquiterpene lactones and other constituents of Centaurea napifolia.
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Aerial parts of Centaurea napifolia furnished the sesquiterpene lactones cnicin, 4'-acetoxycnicin, melitensin, dehydromelitensin, two known esters of dehydromelitensin, lappaol and a lappaol isomer, and a 1,2-diacylated glucose.
[Further Compounds from Centaurea stoebe.].
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From CENTAUREA STOEBE the following compounds have been isolated: cnicin, salonitenolide, salonitenolid-8- O-(4'-acetoxy-5'-hydroxyangelate), stoebenolide, 3-hydroxy-2-methylbutyrolactone, and 3-(3, 4-dihydroxy-5-methoxyphenyl)-prop-1-yl 3-hydroxy-11-methyloctadecanoate.
Bioactivity-guided isolation of anti-proliferative compounds from endemic Centaurea kilaea.
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BACKGROUND
The genus Centaurea L. (Asteraceae) is one of the largest genera in Turkey. Compounds and extracts obtained from different Centaurea species have significant anti-cancer activity against various cancer cell lines.
OBJECTIVE
To determine the anti-proliferative activity of isolates from the
Isolation of Chemical Constituents of Centaurea virgata Lam. and Xanthine Oxidase Inhibitory Activity of the Plant Extract and Compounds.
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BACKGROUND
Centaurea virgata Lam. is a species widely used in the traditional medicine in Turkey for the treatment of diabetes, allergy and gastric ulcers. The rationale of its use in the therapy has not been studied previously, therefore the present work aimed at the chemicalpharmacological
Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L.
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Bioassay-guided fractionation of the chloroform extract of Centaurea jacea L. afforded the isolation of cirsiliol, apigenin, hispidulin, eupatorin, isokaempferide, axillarin, centaureidin, 6-methoxykaempferol 3-methyl ether, trachelogenin, cnicin, 4'-acetylcnicin and three aliphatic glucose
Sesquiterpene lactones from Centaurea spinosa and their antibacterial and cytotoxic activities.
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Ten sesquiterpene lactones, 8alpha-O-(3,4-dihydroxy-2-methylenebutanoyloxy)sonchucarpolide (4-epi-malacitanolide) (1), 8alpha-O-(4-acetoxy-2-hydroxymethylbuten-2-oyloxy)-4-epi-sonchucarpolide (2), malacitanolide (3), its 4'-acetyl derivative (4),
Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria.
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The antiproliferative effects of n-hexane, chloroform and aqueous methanol extracts prepared from the whole plant of Centaurea arenaria M.B. ex Willd. were investigated against cervix adenocarcinoma (HeLa), breast adenocarcinoma (MCF7) and skin epidermoid carcinoma (A431) cells, using the MTT assay.
Plant-derived natural products exhibiting activity against formosan subterranean termites (Coptotermes formosanus).
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The Formosan subterranean termite, Coptotermes formosanus Shiraki, is among the most devastating termite pests. Natural products derived from plant extracts were tested in a discovery programme for effective, environmentally friendly termite control agents. Among the natural products tested,
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