3 level intervention: level 1:Self help booklet level 2: CNS delivered intervention level 3: psychologist delivered intervention

level 1 intervention: self help booklet Non study trained CNS will offer assessment, advice, vaginal dilator training where appropriate, arrange topical oestrogens or other creams

Cervical Cancer

Ovarian Cancer

Uterine Cancer

Vaginal Cancer

Vulval Cancer

Psychosexual Dysfunctions

Behavioral: SAFFRON stepped care Stepped care (Improving Access to Psychological Therapies, 2012; Richards et al., 2012) adapted for the gynaecological cancer setting to produce a 3-step model including a clinical assessment and treatment algorithm.
Assessment Algorithm FSFI Interventions
Level 1:
Best available self-help literature on psychosexual difficulties after cancer as judged by the project team and two patient advocates.
Level 2:
A 3-5 session manualised psycho-educational intervention delivered fortnightly by study trained CNSs with taping and supervision for adherence to protocol and manual.
Level 3:
16 weekly session manualised brief psychotherapy adaptation of InterPersonal Therapy, IPT (Interpersonal Psychotherapy for Sexual Adjustment post Gynaecological Cancer, IPT-APGyC)

SAFFRON stepped care

Developing a Stepped Approach to Improving Sexual Function aFteR Treatment fOr gyNaecological Cancer

Developing a Stepped Approach to Improving Sexual Function After Gynaecological Cancer- a Feasibility Study and Randomized Controlled Trial

shows whether interventions have changed sexual functioning

University College, London

Saffron treatment group received saffron tablets daily for 45 days

Barberry group received barberry tablets daily for 45 days

Placebo group received placebo tablets daily for 45 days

Metabolic Syndrome

Hypercholesterolemia

Hypertriglyceridemia

Hyperglycemia

Saffron tablet

Barberry tablet

Placebo tablets received daily for 45 days

Placebo

Birjand University of medical sciences

Crocus Sativus (Saffron) and Berberis Vulgaris (Barberry Fruit) in Metabolic Syndrome

Effect of Crocus Sativus (Saffron) and Berberis Vulgaris (Barberry Fruit) on Metabolic Syndrome

Serum LDL cholesterol after 45 days of treatment in three study groups

Serum total cholesterol after 45 days of treatment in three study groups

serum HDL cholesterol after 45 days of treatment in three study groups

serum triglyceride after 45 days of treatment in three study groups

Fasting Blood Sugar after 45 days of treatment in three study groups

Hematocrit measured after 45 days of treatment

crocus sieberi/antitumoraal middel

Developing a Stepped Approach to Improving Sexual Function aFteR Treatment fOr gyNaecological Cancer

Crocus Sativus (Saffron) and Berberis Vulgaris (Barberry Fruit) in Metabolic Syndrome

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