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Taking into consideration regulative aspects and perceptible interrelations with pressor and depressor systems some typical alterations of the carbohydrate and lipid metabolism in patients with essential arterial hypertension are summarized. An increased hormone-induced lipolysis is associated with
The effects of MPC-1304, a new calcium channel blocker, on blood pressure, serum lipoproteins, and carbohydrate metabolism were compared with those of atenolol in a group of patients with mild to moderate essential hypertension. Systolic and diastolic pressures were significantly decreased by both
Carbohydrate tolerance was studied in ten patients with essential hypertension, both before and after one year of treatment with a diuretic: bumethanide. No significant differences were found in glucose and insulin values. Results show hyperglycemia aggravation to be minimal with bumethanide,
Fourteen outpatients with mild-to-moderate essential hypertension were treated with perindopril (4-8 mg once daily) for a 16-week period. It was observed that the drug was effective in lowering blood pressure without inducing changes in blood lipids commonly observed with other hypotensive agents.
The development of essential hypertension (EH) is proposed to be the result of a cascade of metabolic alterations, with high insulin levels/hyperinsulinemia and an abnormal reaction to the vasodilatory effect of insulin as the initiating factors. It is well established that insulin causes