Probiotic tablets (containing a mix of Lactobacillus rhamnosus PB01, DSM 14869 and Lactobacillus curvatus EB10, DSM 32307, 1*10(9) CFU) 2 times/day for 12 weeks

Gingivitis

Probiotic tablet twice a day for 12 weeks

Probiotic tablet

Placebo tablet

University of Copenhagen, Dept. of Odontology

Impact of Oral Probiotics on Oral Homeostasis

Impact of Oral Probiotics on Oral Homeostasis - a Randomized Double Blind Study

Alpha-diversity measured by shannon index

Mean levels of NGAL (mg/mL) measured by ELISA

Mean levels of transferrin (mg/mL) measured by ELISA

Mean levels of PI (% of sites with positive recordings)

Mean levels of GI (% of sites with positive recordings)

Mean levels of BI (% of sites with positive recordings)

Daniel Belstrøm, DDS, PhD

Associate professor, Principal Investiator, dr. odont., PhD, DDS

University of Copenhagen

PI are the only one aware of participant status.

Wound Healing

Under local anesthesia 2% lignocaine hydrochloride using a No. 15 BP (Bard Parker) blade full thickness flap will be elevated till the MGJ (mucogingival junction) using a small periosteal elevator and a partial-thickness flap will be raised beyond the mucogingival junction to allow a passive coronal displacement of the flap completely covering the CEJ without tension.
The donor site consisting of 2 mm thick palatal connective tissue graft will be harvested from the premolar to the first molar area using the 'trap door' technique.14 The connective tissue graft will be secured in position with 4-0 absorbable sutures in recipient sites.
The flaps will be stabilized with sling suture in a coronal position, followed by interrupted suture on releasing incisions in an apico-coronal direction using 4-0 absorbable sutures.

coronally advanced flap with subepithelial connective tissue graft

Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY

gelatinase/cariës

Impact of Oral Probiotics on Oral Homeostasis

Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY

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