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10 resultaten
Derivative of isoindigo, indigo and indirubin for the treatment of cancer
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TECHNICAL FIELD
The invention relates to new and useful compounds that are derivatives of isoindigo, indigo and indirubin. The invention further relates to the use of these derivatives in the treatment of cancer in animals.
BACKGROUND
Prevention and treatment of cancer has significantly improved in
Derivatives of isoindigo, indigo and indirubin and methods of treating cancer
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TECHNICAL FIELD
The invention relates to new and useful compounds that are derivatives of isoindigo, indigo and indirubin and their use in treating solid tumor cancer in a subject. The invention further relates to methods of synthesizing the useful derivatives.
BACKGROUND
Prevention and treatment of
Breast cancer therapeutic agent containing 5'-hydroxy-5-nitro-indirubin-3'-oxime as active ingredient
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This U.S. application claims priority to Korean Patent Application No. 10-2016-157929 filed on Nov. 25, 2016, the contents of which are incorporated herein by reference.
TECHNICAL FIELD
The present invention relates to a breast cancer therapeutic agent containing
Indirubin derivative having highly selective cytotoxicity for malignant tumors
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TECHNICAL FIELD
The present invention relates to a new indirubin derivative or a salt thereof and to a pharmaceutical comprising the derivative or a salt thereof.
BACKGROUND ART
Cancer (malignant tumor) is a disease ranked as the first leading cause of death, for which new therapies are needed. At
Nanoparticles of indirubin, derivatives thereof and methods of making and using same
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BACKGROUND OF THE INVENTION
Indirubin is extracted from the indigo plant. Indirubin is a constituent of a traditional Chinese herbal formula, Dang Gui Long Hui Wan used in the treatment of chronic myelogenous leukemia (CML). It has also been used in Asia as a systemic treatment for psoriasis.
In
Indirubin derivatives, and uses thereof
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of U.S. patent application Ser. No. 13/758,921, filed Feb. 4, 2013, which claims the benefit of U.S. Provisional Patent Application No. 61/594,934, filed Feb. 3, 2012; and U.S. Provisional Patent Application No.
Indirubin-3'-oxime derivatives as potent cyclin dependent kinase inhibitors
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This is a 371 national phase application of PCT/KR2011/000611 filed 28 Jan. 2011, claiming priority to Korean Patent Application No. 10-2010-0010715 filed 5 Feb. 2010, the contents of which are incorporated herein by reference.
TECHNICAL FIELD
The present invention relates to an indirubin-3'-oxime
Indirubin derivatives and uses thereof in treating chronic myelogenous leukemia
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BACKGROUND OF THE INVENTION
Signal Transducer and Activator of Transcription (STAT) proteins have essential functions in normal cytokine signaling and are frequently constitutively activated in human tumor cells (Yu and Jove, 2004). STATs have key roles in regulating cell proliferation, survival,
5-bromo-indirubins
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REFERENCE TO A "SEQUENCE LISTING," A TABLE, OR A COMPUTER PROGRAM LISTING APPENDIX SUBMITTED ON A COMPACT DISK
The Sequence Listing written in file 48440-651C01US_ST25.TXT, created on Feb. 9, 2018, 28,358 bytes, machine format IBM-PC, MS-Windows operating system, is hereby incorporated by
Conjugate of benzofuranone and indole or azaindole, and preparation and uses thereof
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CROSS REFERENCE TO RELATED APPLICATIONS
This application is a national phase filing under 35 U.S.C. 371 of International Application No. PCT/CN2014/000525, filed May 26, 2014, which claims priority to Chinese Patent Application No. CN201310202029.3, filed May 28, 2013, the disclosures of each of
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