Citrulline genration test before starting enteral nutrition
At ICU admission, a blood sample is collected (i) before and (ii) 90 minutes after N2-L-Alanyl-L-Glutamine administration

Enteral Nutrition

Intensive Care Unit

Biomarkers

20 gr of 10% N2-L-Alanyl-L-Glutamine, dilution in 200 ml of water for injection, intravenous perfusion over 30 minutes

N2-L-Alanyl-L-Glutamine (Substance)

Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients

Feeding intolerance evaluated at day-3 of enteral nutrition Citrulline generation test: variation of citrullinemia/90 minutes

Feeding intolerance at day-3 of enteral nutrition Citrullinemia measured the first day just before initiation of enteral nutrition

Link between citrullinemia and cumulative amount of enteral nutrition administred during the first three days of ICU stay

Link between citrullinemia levels and occurrence of acute mesenteric ischemia and inhalation pneumopathy during the first week of enteral nutrition

Centre Hospitalier Universitaire de Besancon

A bolus of Dipeptiven (Glutamine-Alanine) administered intravenously over 30 minute (20 gramme of N2-L-Alanyl-L-Glutamine solution, dilution in 200 ml of water for injection, intravenous perfusion over 30 minutes).

One side of the face will be randomly chosen as the treatment side

The other side of the face will be randomly chosen as the control

Skin Care

The skin care regimen we will be testing includes ingredients such Hyaluronic acid 1%, Vitamin E Acetate, Vitamin A Acetate, Co-enzyme Q 10, L-Arginine, L-glutamine, Phytonadione, Argireline Peptide solution, GABA, Vitamin C, glycolic acid, and Fenugreek.

Skin Care Cream

The placebo will be a formula with no active ingredients

Placebo

WSUPG Dermatology

Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream

The primary endpoint of this study is a 15% reduction in facial wrinkle count as measured by the Visia complexion analysis software.

A secondary endpoint of the study will be a 10% reduction in skin roughness as measured by an OCT image analysis

Steven D Daveluy

Assistant Professor

Wayne State University

Patients will engage in a split face trial, where each participant uses the vehicle on one side of the face and active ingredient treatment cream on the other side

Block randomization will be utilized to determine which side will be the treatment side.

l glutamine/atrofie

Citrullinemia for the Prediction of Enteral Nutrition Tolerance Among Critically Ill Patients

Investigating the Wrinkle Reduction Potential of a Novel Compounded Skin Care Cream

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