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ligularia rumicifolia/glutathione
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Involvement of intracellular glutathione in regulating isoline-induced cytotoxicity in human normal liver L-02 cells.
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Pyrrolizidine alkaloid isoline is isolated from the traditional Chinese medicine Ligularia duciformis. Our previous reports have already demonstrated isoline-induced liver injury in mice. The present study is designed to observe the involvement of intracellular reduced glutathione (GSH) in
Pyrrolizidine alkaloid clivorine-induced oxidative stress injury in human normal liver L-02 cells.
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Clivorine is an otonecine-type pyrrolizidine alkaloid isolated from the traditional Chinese medicine Ligularia hodgsonii Hook. Pyrrolizidine alkaloids (PAs) are well-known hepatotoxins widely distributed around the world. The present study sought to evaluate clivorineinduced oxidative injury in
Pyrrolizidine alkaloid isoline-induced oxidative injury in various mouse tissues.
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Isoline is a retronecine-type pyrrolizidine alkaloid (PA) isolated from the traditional Chinese medicinal herb Ligularia duciformis. The present investigation was carried out to evaluate isoline-induced oxidative injury in various important mouse organs. Various tissue samples were collected after
Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity.
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Pyrrolizidine alkaloid (PA) clivorine, isolated from traditional Chinese medicinal plant Ligularia hodgsonii Hook, has been shown to induce apoptosis in hepatocytes via mitochondrial-mediated apoptotic pathway in our previous research. The present study was designed to observe the protection of
Ligularia fischeri leaf extract prevents the oxidative stress in DBA/1J mice with type II collagen-induced arthritis.
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The generation of free radicals has been implicated in the causation of several diseases and compounds that can scavenge free radicals have great potential in ameliorating these disease processes. The present study was aimed to investigate the possible antioxidant potential of Ligularia fischeri
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