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migraine disorders/obesitas
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Bladzijde 1 van 163 resultaten
3-aminopyrrolidone derivatives
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FIELD OF THE INVENTION
This invention is related to 3-aminopyrrolidone derivatives and analogues of the following general formula I
##STR00001##
and pharmaceutically acceptable salts thereof, that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating
1,3-dialkylurea derivative
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TECHNICAL FIELD
The present invention relates to a novel 1,3-dialkylurea derivative which has inhibitory effects on endopeptidase 24.11 and is useful as a therapeutic agent for cardiovascular diseases such as heart failure and hypertension, renal diseases such as renal failure, gastroenteric
Alicyclic imidazoles as H3 agents
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FIELD OF THE INVENTION
The present invention is directed to alicyclic imidazoles which interact with the histamine H.sub.3 receptor as agonists, antagonists or inverse agonists; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the
Indole derivatives as 5-HT1 agonists
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
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FIELD OF THE INVENTION
The present invention is directed to a novel crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide, pharmaceutical compositions containing said crystalline form and the use of said crystalline form in the treatment anxiety and related
Ergoline derivatives of 2-propinylamine, a process for the manufacture thereof and the use thereof for medicaments
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TECHNICAL FIELD OF THE INVENTION
The present invention belongs to the field of pharmaceutical industry and refers to novel ergoline derivatives of optionally substituted 2-propinylamine, which are useful in the pharmaceutical industry as active substances for the manufacture of medicaments used in
2,3,4,4a-tetrahydro-1H-pyrazino(1,2-a) quinoxalin-5(6H)one derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to derivatives of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2,-a]quinoxalin-5(6H)ones which are serotonin 5-hydroxytryptamine 2.sub.C (5HT.sub.2C) receptor agonists useful for the treatment of disorders such as obsessive-compulsive disorder,
Modulation of substance P by compounds containing calcium sulfate and methods relating thereto
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TECHNICAL FIELD
The present invention relates generally to a method of modulating substance P by compounds containing calcium sulfate, particularly syngenite, gorgeyite and gypsum, and more specifically, to the synthesis of such compounds as well as their use to treat a variety of conditions
Substituted sulfamide derivatives
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FIELD OF THE INVENTION
The present invention is directed to novel substituted sulfamide derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives form in the treatment of anxiety and related disorders; bipolar depression and mania; depression; epilepsy and
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives
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This is the national stage under 35 U.S.C. .sctn.371 of application no. PCT/US92/08306 filed Oct. 6, 1992.
BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives
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BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other
Indole derivatives as 5-HT1 agonists
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This application is a 371 of PCT/US93/01667 filed Mar. 3, 1993.
BACKGROUND OF THE INVENTION
The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of
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