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13 resultaten
Formulation and characterization of atropine sulfate in albumin-chitosan microparticles for in vivo ocular drug delivery.
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The overall study goal was to produce a microparticle formulation containing atropine sulfate for ocular administration with improved efficacy and lower side effects, compared with that of the standard marketed atropine solution. The objective was to prepare an atropine sulfate-loaded bovine serum
Concentration-related mydriasis in a patient with renal dysfunction treated with phenytoin.
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BACKGROUND
There is very limited evidence concerning phenytoin-related mydriasis.
METHODS
A 59-year-old male was hospitalized in the intensive care unit due to a head injury. During his hospitalization, phenytoin was administrated. Some days later he presented bilateral mydriasis. At that time he
Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs.
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The breakdown of blood-tear barrier that occurs with ocular pathology allows for large amounts of albumin to leak into the tear fluid. This process likely represents an important restriction to drug absorption in ophthalmology, as only the unbound drug is transported across the ocular tissue
[Correlation between total aqueous protein concentrations and photon counts in rabbits].
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We studied the correlation between photon counts of the aqueous flare and total aqueous protein concentrations in rabbit eyes. After mydriasis, a predetermined volume of the aqueous humor was aspirated and photon counts of the secondary aqueous was measured using a laser flare-cell meter. In vitro
Ambulatory blood pressure monitoring and progression of retinopathy in normotensive, normoalbuminuric type 1 diabetic patients: a 6-year follow-up study.
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To investigate the relationship between diabetic retinopathy (DR) and 24-h ambulatory blood pressure (ABP) in a cohort of normotensive, normoalbuminuric type 1 diabetic patients. This is a 6.1+/-3.3 year prospective study of 44 normotensive, normoalbuminuric type 1 diabetic patients. ABP was
[Acute quinine poisoning treated with high dose of diazepam].
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BACKGROUND
High concentrations of quinine, the drug of choice for severe malaria, are toxic to the cardiovascular system, producing hypotension and abnormal myocardial conduction.
METHODS
An 8 year-old girl was admitted for fever, headache and arthralgias. Examination of a thick film of blood showed
[A 13-week oral repeated dose toxicity study of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a novel drug for urinary frequency and incontinence, in dogs followed by a 5-week recovery test].
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A 13-week oral repeated dose toxicity study of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate (NS-21), a new drug for the treatment of urinary frequency and incontinence, was conducted in beagle dogs. Male and female dogs were
[Thirteen-week oral toxicity study of propiverine hydrochloride in dogs].
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A subacute oral toxicity study of propiverine hydrochloride (P-4), a new anti-pollakiuria agent, was carried out at dose-levels of 0, 1, 3, 9, and 27 mg/kg/day using male and female beagle dogs. They were treated for 13 weeks, followed by 5 weeks recovery period. The results obtained from the
Prevalence of retinopathy in Caucasian type 2 diabetic patients from the South of Brazil and relationship with clinical and metabolic factors.
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Diabetic retinopathy (DR) is a sight-threatening chronic complication of diabetes mellitus and is the leading cause of acquired blindness in adults. In this cross-sectional study, we investigated the prevalence of and the factors associated with DR in an analysis of 210 consecutive and unrelated
Diabetic microangiopathy.
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Microvascular complications of diabetes include retinopathy, nephropathy and neuropathy. The first signs of these complications may develop in children and adolescents, particularly if insulin treatment has been inadequate. The mechanisms by which diabetic microangiopathy develop are not known, but
Measurement of aqueous cells and flare in normal eyes.
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(abstractThe Kowa laser cell flare meter has been recently introduced to quantify the assessment of aqueous cells and flare in vivo by measurement of light scattering from a low power HeNe beam. Computer analysis of this scattered light can distinguish cells (expressed as cell count) from protein
Inflammation and endothelial dysfunction are associated with retinopathy: the Hoorn Study.
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OBJECTIVE
The exact pathogenesis of retinopathy in diabetic and non-diabetic individuals is incompletely understood, but may involve chronic low-grade inflammation and dysfunction of the vascular endothelium. The aim of this study was to investigate the association of inflammation and endothelial
Prevalence and risk factors for diabetic retinopathy in the multiethnic population of Mauritius.
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This study examines the prevalence of, and risk factors for, diabetic retinopathy in Asian Indian, Chinese, and Creole Mauritians in whom there is an increasing prevalence of non-insulin-dependent diabetes mellitus (NIDDM). As part of a population-based survey on the Indian Ocean island of Mauritius
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