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psorospermum aurantiacum/antitumoraal middel
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Anticancer and antimicrobial activities of some antioxidant-rich cameroonian medicinal plants.
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Traditional remedies have a long-standing history in Cameroon and continue to provide useful and applicable tools for treating ailments. Here, the anticancer, antimicrobial and antioxidant activities of ten antioxidant-rich Cameroonian medicinal plants and of some of their isolated compounds are
Antineoplastic agents from higher plants: application of tandem mass spectrometry to xanthones from Psorospermum febrifugum.
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Psorospermum febrifugum was examined using tandem ms for the presence of 3',4'-deoxypsorospermin-4'-chloro-3'-ol and psorospermin. Collision-induced dissociation at both high and low energy is used to bring about fragmentation. Daughter spectra were interpreted to reveal characteristic
Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.
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Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plant Psorospermum cf. molluscum using bioassay-guided fractionation with the Escherichia coli SOS chromotest. The structures of the new dihydrofuranoxanthones, designated
Psorospermin, a new antileukemic xanthone from Psorospermum febrifugum.
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An ethanolic extract of Psorospermum febrifugum was fractionated with antileukemic activity in vivo in the P388 lymphocytic leukemia in mice and in vitro in the KB cell culture system used as a guide. The new antileukemic xanthone psorospermin 1 was isolated, and its structure was elucidated. The
Mechanism of action of the antileukemic xanthone psorospermin: DNA strand breaks, abasic sites, and protein-DNA cross-links.
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Psorospermin, a cytotoxic dihydrofuranoxanthone isolated from Psorospermum febrifugum, produced aberrant simian virus 40 DNA replication intermediates when added to lytically infected CV-1 monkey kidney cells. The aberrant viral intermediates showed dose-dependent DNA strand breaks and protein-DNA
Natural products as a source of potential cancer chemotherapeutic and chemopreventive agents.
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Recent advances in the chemistry of novel bioactive natural products are reported. This research is directed to the exploration of plants with confirmed activity in bioassays designed to detect potential cancer chemotherapeutic and chemopreventive agents. Structural work and chemical studies are
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